Pirates vs. Cardinals Prediction, Odds, Picks - May 6

Lars Nootbaar and the St. Louis Cardinals hit the field on Tuesday at Busch Stadium against Paul Skenes, who is starting for the Pittsburgh Pirates. First pitch is at 7:45 p.m. ET. The Pirates are favored in this one, at -120, while the underdog Cardinals have +100 odds to upset. Pittsburgh is a 1.5-run favorite (at +145 odds). The game's over/under has been set at 7 runs.

Check out everything you need to know from a betting perspective on the Pirates-Cardinals game, regarding the run line, moneyline and total, plus expert picks.

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Pirates vs. Cardinals Highlights | MLB on FOX

Check out the best moments between the Pittsburgh Pirates and the St. Louis Cardinals.

Pirates vs. Cardinals Game Information & Odds

• When: Tuesday, May 6, 2025 at 7:45 p.m. ET
• Where: Busch Stadium in St. Louis, Missouri
• How to watch on TV: FDSMW and SportsNet PT

Pirates vs. Cardinals Prediction

• Score Prediction: Cardinals 5, Pirates 4
• Total Prediction: Over 7 runs
• Win Probabilities: Pirates 57%, Cardinals 43%

Pirates vs. Cardinals Betting Insights

• This season, the Pirates have won five out of the 14 games, or 35.7%, in which they've been favored.
• Pittsburgh has a record of 3-8 in games when sportsbooks favor them by at least -120 on the moneyline.
• The moneyline for this contest implies a 54.5% chance of a victory for the Pirates.
• The Cardinals have come away with 12 wins in the 25 contests they have been listed as the underdogs in this season.
• St. Louis has a win-loss record of 6-10 when favored by +100 or worse by oddsmakers this year.
• The moneyline set for this matchup implies the Cardinals have a 50% chance of coming away with a victory in the contest.

Pirates Recent Betting Performance

• The Pirates were favored on the moneyline three times over the last 10 games, but they lost every matchup.
• Over their last 10 matchups -- all had a set run total -- the Pirates and their opponents combined to hit the over on the total six times.
• The Pirates have a 2-8-0 record against the spread over their past 10 games.

Pirates Recent Stats

Pirates Player Insights

• Oneil Cruz has left the yard eight times this season, the highest mark on the Pirates, while hitting .252 with 18 RBI.
• In all of the majors, Cruz ranks 20th in home runs and 53rd in RBI.
• Bryan Reynolds has been productive as he leads his team with 19 runs batted in.
• Reynolds ranks 59th in home runs and 43rd in RBI among all hitters in MLB.
• Andrew McCutchen leads the Pirates with a .253 batting average.
• Enmanuel Valdez is hitting .221 with four doubles, two triples, two home runs and 11 walks.

Pirates Team Props

Cardinals Recent Betting Performance

• In six games as underdogs over the last 10 matchups, the Cardinals have a record of 4-2.
• The Cardinals and their opponents have combined to hit the over seven times in their last 10 games with a total.
• The Cardinals are 5-5-0 ATS over their last 10 games.

Cardinals Recent Stats

Cardinals Player Insights

• Nootbaar has swatted a team-high five long balls.
• Nootbaar's home run total puts him 59th in the majors, and he ranks 53rd in RBI.
• Brendan Donovan has 19 runs batted in while hitting .336. Each is tops on the club.
• Donovan is currently 130th in homers and 43rd in RBI in the major leagues.
• Nolan Arenado has nine doubles, three home runs and 16 walks while hitting .256.
• Victor Scott II has six doubles, a triple, two home runs and 12 walks while batting .284.

Cardinals Team Props

Pirates vs. Cardinals Highlights | MLB on FOX

Check out the best moments between the Pittsburgh Pirates and the St. Louis Cardinals.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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