Pirates vs. Athletics Prediction, Odds, Picks - September 21

The Pittsburgh Pirates and Nick Yorke will square off against the Athletics and Tyler Soderstrom at PNC Park on Sunday, with the first pitch at 1:35 p.m. ET. The favored Pirates have -122 moneyline odds against the underdog Athletics, who are listed at +102. The Athletics are favored on the run line (-1.5). The total for the game is listed at 8.5 runs.

Take a look at everything you need to know from a betting perspective on the Pirates-Athletics game, regarding the run line, moneyline and total, plus expert picks.

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Athletics vs. Pirates Highlights | MLB on FOX

Check out the best highlights between the Athletics and the Pittsburgh Pirates.

Pirates vs. Athletics Game Information & Odds

• When: Sunday, September 21, 2025 at 1:35 p.m. ET
• Where: PNC Park in Pittsburgh, Pennsylvania
• How to watch on TV: SportsNet PT and NBCS-CA

Pirates vs. Athletics Prediction

• Score Prediction: Pirates 5, Athletics 4
• Total Prediction: Over 8.5 runs
• Win Probabilities: Pirates 52%, Athletics 48%

Pirates vs. Athletics Betting Insights

• This season, the Pirates have been favored 44 times and won 21, or 47.7%, of those games.
• This season, the Pirates have won 15 of their 31 games, or 48.4%, when favored by at least -122 on the moneyline.
• Oddsmakers have implied with the moneyline set for this matchup that the Pirates have a 55% chance to win.
• The Athletics have been victorious in 55, or 47.4%, of the 116 contests they have been chosen as underdogs in this season.
• This year, the Athletics have won 43 of 101 games when listed as at least +102 or better on the moneyline.
• The moneyline set for this matchup implies the Athletics have a 49.5% chance of coming away with a victory in the contest.

Pirates Recent Betting Performance

• The Pirates have a 1-4 record from the five games they were moneyline favorites over their last 10 matchups.
• Over their last 10 outings, the Pirates and their opponents combined to hit the over two times (all 10 of the games had set totals).
• The Pirates' record against the spread is 4-6-0 over their past 10 games.

Pirates Recent Stats

Pirates Player Insights

• Bryan Reynolds comes into Sunday's game as the Pirates top run producer, collecting 73 RBI while connecting on 16 home runs in 2025. His .243 average is also best on the squad.
• Reynolds' home runs place him 121st in MLB, and he ranks 69th in RBI.
• Reynolds takes a hitting streak of two games into this matchup. During his last five outings he is hitting .222 with a double, a home run, three walks and two RBIs.
• Andrew McCutchen has 22 doubles, 13 home runs and 65 walks while batting .240.
• Among all major league hitters, McCutchen ranks 156th in home runs and 133rd in RBI.
• Oneil Cruz has a team-high 19 homers.
• Spencer Horwitz has 23 doubles, nine home runs and 39 walks while hitting .259.

Pirates Team Props

Athletics Recent Betting Performance

• The Athletics have played as underdogs in six of their past 10 games and won five of those contests.
• When it comes to hitting the over, the Athletics and their opponents are 2-7-1 in their last 10 games with a total.
• The Athletics have a record of 7-3-0 ATS over their last 10 games.

Athletics Recent Stats

Athletics Player Insights

• Brent Rooker is hitting .264 with 40 doubles, three triples, 30 home runs and 61 walks.
• Among all hitters in the majors, Rooker is 19th in home runs and 30th in RBI.
• Soderstrom has driven in the most runs for the Athletics with 90 runs batted in.
• Soderstrom is 49th among all hitters in the majors in homers, and 24th in RBI.
• Nick Kurtz has 33 home runs, tops in the clubhouse.
• Jacob Wilson leads the Athletics with a team-high batting average of .318.

Athletics Team Props

Athletics vs. Pirates Highlights | MLB on FOX

Check out the best highlights between the Athletics and the Pittsburgh Pirates.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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