Phillies vs. Astros Prediction, Odds, Picks - June 25

Updated Jun. 25, 2025 8:00 p.m. ET

Data Skrive

Kyle Schwarber and the Philadelphia Phillies will play Jeremy Pena and the Houston Astros on Wednesday at Daikin Park, at 8:10 p.m. ET. The Phillies are -156 moneyline favorites for this matchup with the Astros (+131). Philadelphia is favored on the run line (-1.5 with +112 odds). The over/under for the matchup is listed at 7.5 runs.

Here's everything you need to know from a betting perspective on the Phillies-Astros game, regarding the run line, moneyline and total, plus expert picks.

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Phillies vs. Astros Game Information & Odds

When: Wednesday, June 25, 2025 at 8:10 p.m. ET
Where: Daikin Park in Houston, Texas
How to watch on TV: SCHN and NBCS-PH

Favorite	Favorite Moneyline	Underdog Moneyline	Total	Over Total Odds	Under Total Odds	Run Line	Favorite Run Line Odds	Underdog Run Line Odds
Phillies	-156	+131	7.5	+102	-123	-1.5	+112	-133

Phillies vs. Astros Prediction

Score Prediction: Astros 5, Phillies 4
Total Prediction: Over 7.5 runs
Win Probabilities: Phillies 53%, Astros 47%

Phillies vs. Astros Betting Insights

This season, the Phillies have won 42 out of the 64 games, or 65.6%, in which they've been favored.
This season Philadelphia has won 30 of its 39 games, or 76.9%, when favored by at least -156 on the moneyline.
The sportsbooks' moneyline implies a 60.9% chance of a victory for the Phillies.
The Astros have come away with 13 wins in the 24 contests they have been listed as the underdogs in this season.
This season, Houston has been victorious two times in three chances when named as an underdog of at least +131 or longer on the moneyline.
Sportsbooks have implied with the moneyline set for this matchup that the Astros have a 43.3% chance of pulling out a win.

Phillies Recent Betting Performance

The Phillies went 7-1 across the eight games they were favored on the moneyline in their last 10 matchups.
In their last 10 matchups, the Phillies and their opponents combined to hit the over four times (all 10 of the games had set totals).
The Phillies are 6-4-0 against the spread over their past 10 games.

Phillies Recent Stats

Stat	Avg/Total
Record	7-3
Runs Per Game	4.9
HR	11
ERA	3.27
K/9	8.2

Phillies Player Insights

Schwarber is the Phillies best power option, crushing 24 long balls this season in addition to accumulating 55 RBI, both team highs.
Of all batters in baseball, Schwarber ranks fifth in home runs and 11th in RBI.
Trea Turner is batting .300 to lead his team.
Turner ranks 97th in homers and 90th in RBI among all hitters in MLB.
Turner carries a two-game streak with at least one hit into this contest. In his last five games he is hitting .238 with a double and an RBI.
Nick Castellanos is batting .285 with 21 doubles, a triple, eight home runs and 17 walks.
Castellanos is on a four-game hitting streak entering this contest. During his last five outings he is batting .350 with three doubles, a home run, a walk and five RBIs.
Alec Bohm is hitting .287 with 11 doubles, a triple, seven home runs and 16 walks.

Phillies Team Props

	Hits O/U	Total Bases O/U	HR O/U	RBI O/U
Trea Turner	1.5 (+170)	1.5 (-115)	-	0.5 (+160)
Nick Castellanos	1.5 (+180)	1.5 (+100)	-	0.5 (+145)
Alec Bohm	1.5 (+190)	1.5 (-120)	-	0.5 (+140)
Zack Wheeler	-	-	-	-
Johan Rojas	-	-	-	-

Astros Recent Betting Performance

Over the past 10 games, the Astros have been underdogs twice and split those games 1-1.
When it comes to hitting the over, the Astros and their opponents are 4-5-1 in their last 10 games with a total.
The Astros are 3-7-0 ATS over their last 10 games.

Astros Recent Stats

Stat	Avg/Total
Record	7-3
Runs Per Game	4.7
HR	17
ERA	3.40
K/9	10.2

Astros Player Insights

Pena leads the Astros with a .326 batting average.
Among all batters in MLB, Pena ranks 59th in homers and 57th in RBI.
Isaac Paredes has hit 16 home runs with 45 RBI, leading the team in both categories.
Among all major league hitters, Paredes is 18th in home runs and 32nd in RBI.
Jose Altuve has 10 doubles, 12 home runs and 25 walks while hitting .266.
Jake Meyers has 13 doubles, a triple, three home runs and 23 walks while hitting .307.