Padres vs. Mariners Prediction, Odds, Picks - May 18

Manny Machado and the San Diego Padres will take on Cal Raleigh and the Seattle Mariners at PETCO Park on Sunday. The Padres are favored in this one, at -145, while the underdog Mariners have +121 odds to win. San Diego is the run-line favorite (-1.5). The total is 7.5 runs for the contest.

Check out everything you need to know from a betting perspective on the Padres-Mariners game, regarding the run line, moneyline and total, plus expert picks.

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Padres vs. Mariners Game Information & Odds

• When: Sunday, May 18, 2025 at 4:10 p.m. ET
• Where: PETCO Park in San Diego, California
• How to watch on TV: SDPA and ROOT Sports NW

Padres vs. Mariners Prediction

• Score Prediction: Padres 5, Mariners 4
• Total Prediction: Over 7.5 runs
• Win Probabilities: Padres 54%, Mariners 46%

Padres vs. Mariners Betting Insights

• This season, the Padres have been favored 25 times and won 17, or 68%, of those games.
• San Diego is 11-6 this season when entering a game favored by -145 or more on the moneyline.
• The moneyline for this contest implies a 59.2% chance of a victory for the Padres.
• The Mariners have won in 10, or 55.6%, of the 18 contests they have been named as odds-on underdogs this year.
• Seattle has a win-loss record of 4-3 when favored by +121 or worse by sportsbooks this year.
• Bookmakers have implied with the moneyline set for this matchup that the Mariners have a 45.2% chance of pulling out a win.

Padres Recent Betting Performance

• The Padres have a 4-4 record from the eight games they were favored on the moneyline over their last 10 matchups.
• Over their last 10 outings, the Padres and their opponents combined to hit the over on the run total six times (all 10 games had set totals).
• The Padres have gone 5-5-0 against the spread over their past 10 games.

Padres Recent Stats

Padres Player Insights

• Fernando Tatis Jr. has gone yard 11 times in the 2025 campaign while knocking in 26 runs, both totals that lead the Padres.
• Of all hitters in baseball, Tatis' home run total places him 11th, and his RBI tally ranks him 39th.
• Tatis has collected a hit in two straight games. In his last five games he is batting .200 with a double, two home runs, three walks and three RBIs.
• Machado has a club-best .323 batting average.
• Machado ranks 169th in homers and 93rd in RBI in the bigs.
• Luis Arraez has five doubles, two triples, three home runs and nine walks while batting .299.
• Arraez will look to build on his five-game hitting in this game. During his last five outings he is batting .368 with a double and a walk.
• Xander Bogaerts has nine doubles, three home runs and 21 walks while batting .252.

Padres Team Props

Mariners Recent Betting Performance

• The Mariners have played as underdogs in six of their past 10 games and won four of those contests.
• When it comes to hitting the over, the Mariners and their opponents are 5-5-0 in their last 10 games with a total.
• The Mariners have five wins against the spread in their last 10 chances.

Mariners Recent Stats

Mariners Player Insights

• Raleigh paces the Mariners with 15 long balls and runs batted in, driving in 31.
• Raleigh's home run total places him second in the majors, and he is 17th in RBI.
• Raleigh has collected a hit in five straight games. During his last five outings he is hitting .353 with a double, three home runs, three walks and six RBIs.
• Jorge Polanco is batting .313 with six doubles, 10 home runs and eight walks.
• Among all major league hitters, Polanco is 17th in homers and 22nd in RBI.
• Julio Rodriguez is hitting .236 with five doubles, two triples, seven home runs and 17 walks.
• Randy Arozarena has 10 doubles, five home runs and 27 walks while batting .243.

Mariners Team Props

Marlins' Cal Quantrill pitches immaculate inning vs. Rays

Miami Marlins pitcher Cal Quantrill pitched an immaculate inning against the Tampa Bays Rays.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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