Padres vs. Diamondbacks Prediction, Odds, Picks - August 6

Nestor Cortes and the San Diego Padres will take the field against the Arizona Diamondbacks and starting pitcher Anthony DeSclafani on Wednesday at Chase Field. The Diamondbacks are listed as +114 moneyline underdogs for this matchup with the favorite Padres (-136). San Diego is a 1.5-run favorite (at +117 odds). The over/under is 9.5 runs for this matchup.

Check out everything you need to know from a betting perspective on the Padres-Diamondbacks game, regarding the run line, moneyline and total, plus expert picks.

Keep up with MLB on FOX Sports.

Padres vs. Diamondbacks Highlights | MLB on FOX

Check out the best moments from this MLB matchup between the San Diego Padres and the Arizona Diamondbacks.

Padres vs. Diamondbacks Game Information & Odds

• When: Wednesday, August 6, 2025 at 9:40 p.m. ET
• Where: Chase Field in Phoenix, Arizona
• How to watch on TV: MLB Network, ARID, and SDPA

Padres vs. Diamondbacks Prediction

• Score Prediction: Diamondbacks 5, Padres 4
• Total Prediction: Under 9.5 runs
• Win Probabilities: Padres 51%, Diamondbacks 49%

Padres vs. Diamondbacks Betting Insights

• This season, the Padres have been favored 61 times and won 36, or 59%, of those games.
• San Diego has a record of 23-15 in games when bookmakers favor them by at least -136 on the moneyline.
• The bookmakers' moneyline implies a 57.6% chance of a victory for the Padres.
• The Diamondbacks have been underdogs in 45 games this season and have come away with the win 20 times (44.4%) in those contests.
• This season, Arizona has been victorious 12 times in 20 chances when named as an underdog of at least +114 or longer on the moneyline.
• The Diamondbacks have an implied victory probability of 46.7% according to the moneyline set for this matchup.

Padres Recent Betting Performance

• The Padres were the moneyline favorite in seven of their last 10 games, and they went 5-2 in those matchups.
• In their last 10 outings, the Padres and their opponents combined to go over the run total five times (all 10 games had set totals).
• The Padres' ATS record is 7-3-0 over their past 10 games.

Padres Recent Stats

Padres Player Insights

• Not only does Manny Machado lead the Padres in hitting with his .302 average, he also is their premier power option with 20 home runs and 72 RBI.
• In all of MLB, Machado ranks 29th in homers and 17th in RBI.
• Machado brings a hitting streak of two games into this game. During his last five outings he is hitting .300 with two doubles, two walks and an RBI.
• Fernando Tatis Jr. has 19 doubles, two triples, 17 home runs and 65 walks while batting .261.
• Tatis ranks 60th in home runs and 111th in RBI among all MLB batters this year.
• Luis Arraez is batting .294 with 21 doubles, four triples, six home runs and 23 walks.
• Xander Bogaerts is hitting .268 with 24 doubles, eight home runs and 45 walks.

Padres Team Props

Diamondbacks Recent Betting Performance

• The Diamondbacks have played as underdogs in nine of their past 10 games and won three of those contests.
• In their last 10 games with a total, the Diamondbacks and their opponents have combined to hit the over two times.
• The Diamondbacks have three wins against the spread in their last 10 chances.

Diamondbacks Recent Stats

Diamondbacks Player Insights

• Geraldo Perdomo has driven in the most runs for the Diamondbacks with 75 runs batted in.
• Perdomo is 128th in home runs and 13th in RBI among all batters in the majors.
• Perdomo has collected a hit in three games in a row. In his last five games he is hitting .333 with two doubles and five walks.
• Corbin Carroll has shown his power as he paces his team with 22 home runs.
• Carroll is currently 21st in homers and 65th in RBI in the big leagues.
• Ketel Marte leads the Diamondbacks with a team-high batting average of .287.
• Lourdes Gurriel Jr. has 21 doubles, two triples, 14 home runs and 26 walks while batting .249.

Diamondbacks Team Props

Padres vs. Diamondbacks Highlights | MLB on FOX

Check out the best moments from this MLB matchup between the San Diego Padres and the Arizona Diamondbacks.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

Want great stories delivered right to your inbox? Create or log in to your FOX Sports account, follow leagues, teams and players to receive a personalized newsletter daily.

FOLLOW Follow your favorites to personalize your FOX Sports experience

Arizona Diamondbacks

San Diego Padres