Orioles vs. Red Sox Prediction, Odds, Picks - March 31

Updated Mar. 31, 2025 2:00 p.m. ET

Data Skrive

Ryan O'Hearn and Alex Bregman will be among the stars on display when the Baltimore Orioles face the Boston Red Sox on Monday at 2:35 p.m. ET, at Oriole Park at Camden Yards. The Orioles are -146 moneyline favorites for this matchup with the Red Sox (+123). Baltimore is the run-line favorite (-1.5). The total for the contest is set at 9.5 runs.

Check out everything you need to know from a betting perspective on the Orioles-Red Sox game, regarding the run line, moneyline and total, plus expert picks.

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Orioles vs. Red Sox Game Information & Odds

When: Monday, March 31, 2025 at 2:35 p.m. ET
Where: Oriole Park at Camden Yards in Baltimore, Maryland
How to watch on TV: MASN and NESN

Favorite	Favorite Moneyline	Underdog Moneyline	Total	Over Total Odds	Under Total Odds	Run Line	Favorite Run Line Odds	Underdog Run Line Odds
Orioles	-146	+123	9.5	-114	-106	-1.5	+134	-160

Orioles vs. Red Sox Prediction

Score Prediction: Orioles 6, Red Sox 2
Total Prediction: Under 9.5 runs
Win Probabilities: Orioles 70%, Red Sox 30%

Orioles vs. Red Sox Betting Insights

The Orioles put together a 67-52 record in games they were favored on the moneyline last season (winning 56.3% of those games).
Baltimore had a record of 37-31 when playing as a moneyline favorite with odds of -146 or shorter last year (54.4%).
The Orioles have an implied moneyline win probability of 59.3% in this matchup.
Last season, the Red Sox won 39 out of the 79 games, or 49.4%, in which they were the underdog.

Orioles Player Insights

Adley Rutschman finished last season with 19 home runs, 79 RBI and a batting average of .250.
O'Hearn collected 117 hits, posted an OBP of .334, and a .427 SLG.
Cedric Mullins finished last season with 18 home runs, 54 RBI and a batting average of .234.
Jordan Westburg collected 110 hits, posted an OBP of .312 and a .481 SLG.

Red Sox Player Insights

Jarren Duran racked up 191 hits with a batting average of .285 last season.
Bregman had 30 doubles, two triples, 26 home runs and 44 walks while hitting .260.
Rafael Devers racked up 28 home runs and had 83 runs batted in last season.
Ceddanne Rafaela hit .246 with 23 doubles, five triples, 15 home runs and 15 walks.