Nationals vs. Pirates Prediction, Odds, Picks - September 12

The Washington Nationals and Pittsburgh Pirates will meet on Friday at Nationals Park, at 6:45 p.m. ET, with C.J. Abrams and Bryan Reynolds -- two hot hitters -- expected to step up at the plate. The Pirates are -109 moneyline underdogs for this matchup with the favorite Nationals (-110). Pittsburgh (-1.5) is the favorite on the run line. An 8-run over/under has been set in the matchup.

Check out everything you need from a betting perspective on the Nationals-Pirates game, regarding the run line, moneyline and total, plus expert picks.

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Nationals vs. Pirates Game Information & Odds

• When: Friday, September 12, 2025 at 6:45 p.m. ET
• Where: Nationals Park in Washington D.C.
• How to watch on TV: MASN and SportsNet PT

Nationals vs. Pirates Prediction

• Score Prediction: Pirates 6, Nationals 5
• Total Prediction: Over 8 runs
• Win Probabilities: Nationals 50%, Pirates 50%

Nationals vs. Pirates Betting Insights

• The Nationals have entered the game as favorites 18 times this season and won six, or 33.3%, of those games.
• Washington has a record of 6-12, a 33.3% win rate, when favored by -110 or more by oddsmakers this season.
• The moneyline for this contest implies a 52.4% chance of a victory for the Nationals.
• The Pirates have been victorious in 43, or 41.3%, of the 104 contests they have been chosen as underdogs in this season.
• Pittsburgh has a win-loss record of 42-60 when favored by -109 or worse by bookmakers this year.
• The moneyline set for this matchup implies the Pirates have a 52.2% chance of coming away with a victory in the contest.

Nationals Recent Betting Performance

• The Nationals were listed as the moneyline favorite by bookmakers just two times over the last 10 games, and won both matchups.
• Over their last 10 matchups (all 10 of them had set totals), the Nationals and their opponents combined to go over the run total six times.
• The Nationals have gone 7-3-0 against the spread over their past 10 games.

Nationals Recent Stats

Nationals Player Insights

• Abrams' .266 average leads the Nationals this year. His resume also includes 17 homers and driven in 53 RBI.
• Abrams is 99th in homers and 137th in RBI among all batters in MLB.
• James Wood's 27 home runs and 88 runs batted in both lead his team.
• Wood is 29th in homers and 21st in RBI in the majors.
• Wood carries a three-game streak with at least one hit into this contest. During his last five outings he is batting .350 with three doubles, three walks and two RBIs.
• Luis Garcia is hitting .262 with 27 doubles, a triple, 13 home runs and 26 walks.
• Josh Bell is batting .234 with 13 doubles, a triple, 20 home runs and 54 walks.

Nationals Team Props

Pirates Recent Betting Performance

• In nine games as underdogs over the last 10 matchups, the Pirates have a record of 3-6.
• In their last 10 games with a total, the Pirates and their opponents have combined to hit the over three times.
• The Pirates have five wins against the spread in their last 10 chances.

Pirates Recent Stats

Pirates Player Insights

• Reynolds has driven in the most runs for the Pirates with 70 runs batted in.
• Reynolds' home run total puts him 126th in the majors, and he is 67th in RBI.
• Andrew McCutchen's .244 batting average paces his team.
• McCutchen ranks 150th in home runs and 137th in RBI among all major league hitters this season.
• Oneil Cruz has 19 home runs, tops in the clubhouse.
• Tommy Pham has 17 doubles, a triple, nine home runs and 42 walks while batting .256.

Pirates Team Props

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FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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