Nationals vs. Cardinals Prediction, Odds, Picks - May 11

The Washington Nationals and St. Louis Cardinals will send MacKenzie Gore and Miles Mikolas, respectively, out for the start when the two clubs play on Sunday at Nationals Park, at 1:35 p.m. ET. The favored Nationals have -143 moneyline odds to win against the underdog Cardinals, who are listed at +121. Washington is the favorite on the run line (-1.5 with +149 odds). The matchup's total has been listed at 9 runs.

Take a look at everything you need from a betting perspective on the Nationals-Cardinals game, regarding the run line, moneyline and total, plus expert picks.

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Cardinals vs. Nationals Highlights | MLB on FOX

Check out the best moments between the St. Louis Cardinals and the Washington Nationals.

Nationals vs. Cardinals Game Information & Odds

• When: Sunday, May 11, 2025 at 1:35 p.m. ET
• Where: Nationals Park in Washington D.C.
• How to watch on TV: MASN and FDSMW

Nationals vs. Cardinals Prediction

• Score Prediction: Cardinals 6, Nationals 5
• Total Prediction: Over 9 runs
• Win Probabilities: Nationals 52%, Cardinals 48%

Nationals vs. Cardinals Betting Insights

• This season, the Nationals have won two out of the six games in which they've been favored.
• Washington has played as favorites of -143 or more once this season and lost that game.
• The bookmakers' moneyline implies a 58.8% chance of a victory for the Nationals.
• The Cardinals have won in 13, or 50%, of the 26 contests they have been named as odds-on underdogs this year.
• This season, St. Louis has come away with a win three times in nine chances when named as an underdog of at least +121 or longer on the moneyline.
• Oddsmakers have implied with the moneyline set for this matchup that the Cardinals have a 45.2% chance of pulling out a win.

Nationals Recent Betting Performance

• The Nationals have not been the moneyline favorite in the last 10 games.
• Over their last 10 matchups -- all had a set run total -- the Nationals and their opponents combined to go over the total six times.
• The Nationals have gone 5-5-0 against the spread over their past 10 games.

Nationals Recent Stats

Nationals Player Insights

• James Wood has a team-high 10 homers.
• Including all MLB hitters, Wood ranks 41st in batting average, 26th in on-base percentage, and 14th in slugging.
• Wood has collected a hit in nine straight games. In his last 10 outings he is batting .350 with three doubles, a home run, six walks and two RBIs.
• C.J. Abrams is hitting .299 with seven doubles, two triples, four home runs and eight walks.
• Abrams carries a three-game streak with at least one hit into this contest. In his last five games he is hitting .368 with two doubles, four walks and an RBI.
• Nathaniel Lowe has accumulated a team-best 28 runs batted in.
• Keibert Ruiz's .292 batting average paces his team.
• Ruiz is riding a two-game hitting streak into this one. During his last five outings he is hitting .300 with a double, a walk and an RBI.

Nationals Team Props

Cardinals Recent Betting Performance

• The Cardinals have played as underdogs in five of their past 10 games and have gone 4-1 in those contests.
• In their last 10 games with a total, the Cardinals and their opponents have combined to hit the over seven times.
• The Cardinals have won eight of their last 10 games against the spread.

Cardinals Recent Stats

Cardinals Player Insights

• Lars Nootbaar has launched a team-high five home runs.
• In all of the big leagues, Nootbaar ranks 76th in home runs and 52nd in RBI.
• Nootbaar has collected a hit in three games in a row. During his last five outings he is hitting .238 with two doubles, three walks and three RBIs.
• Brendan Donovan's .327 batting average is a team-high mark.
• Donovan ranks 148th in home runs and 71st in RBI among all MLB hitters this season.
• Nolan Arenado is hitting .263 with nine doubles, three home runs and 16 walks.
• Victor Scott II is hitting .292 with six doubles, a triple, two home runs and 14 walks.

Cardinals Team Props

Cardinals vs. Nationals Highlights | MLB on FOX

Check out the best moments between the St. Louis Cardinals and the Washington Nationals.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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