Mariners vs. Padres Prediction, Odds, Picks - August 25

Manny Machado and the San Diego Padres hit the field on Monday at T-Mobile Park against Bryce Miller, who gets the start for the Seattle Mariners. First pitch is set for 9:40 p.m. ET. The Mariners are -125 moneyline favorites for this matchup with the Padres (+105). Seattle is favored on the run line (-1.5). The total for the contest has been set at 8.5 runs.

Here's everything you need to know from a betting perspective on the Mariners-Padres game, regarding the run line, moneyline and total, plus expert picks.

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Mariners vs. Padres Game Information & Odds

• When: Monday, August 25, 2025 at 9:40 p.m. ET
• Where: T-Mobile Park in Seattle, Washington
• How to watch on TV: ROOT Sports NW and SDPA

Mariners vs. Padres Prediction

• Score Prediction: Mariners 5, Padres 4
• Total Prediction: Over 8.5 runs
• Win Probabilities: Mariners 52%, Padres 48%

Mariners vs. Padres Betting Insights

• This season, the Mariners have won 49 out of the 89 games, or 55.1%, in which they've been favored.
• Seattle has a record of 41-30, a 57.7% win rate, when favored by -125 or more by bookmakers this season.
• The moneyline for this contest implies a 55.6% chance of a victory for the Mariners.
• The Padres have been victorious in 31, or 51.7%, of the 60 contests they have been chosen as underdogs in this season.
• This year, San Diego has won 22 of 47 games when listed as at least +105 or worse on the moneyline.
• The moneyline set for this matchup implies the Padres have a 48.8% chance of walking away with the win.

Mariners Recent Betting Performance

• The Mariners were favored on the moneyline for six of their last 10 games, and they finished 2-4 in those matchups.
• In their last 10 matchups, the Mariners and their opponents combined to go over the run total six times (all 10 games had set totals).
• The Mariners' ATS record is 2-8-0 over their past 10 games.

Mariners Recent Stats

Mariners Player Insights

• Cal Raleigh has gone yard 49 times in the 2025 campaign while knocking in 106 runs, both totals that lead the Mariners.
• Raleigh's home runs put him first in MLB, and he is second in RBI.
• Julio Rodriguez has 24 doubles, four triples, 25 home runs and 33 walks while batting .259.
• Rodriguez is 23rd in home runs in the majors, and 32nd in RBI.
• Josh Naylor paces the Mariners with a .282 batting average.
• Naylor has at least one base hit in three straight games. During his last five outings he is batting .188 with a double, a home run, a walk and three RBIs.
• Eugenio Suarez has 23 doubles, 40 home runs and 35 walks while hitting .236.

Mariners Team Props

Padres Recent Betting Performance

• In five games as underdogs over the last 10 matchups, the Padres have a record of 2-3.
• In their last 10 games with a total, the Padres and their opponents have failed to hit the over six times.
• The Padres have seven wins against the spread in their last 10 chances.

Padres Recent Stats

Padres Player Insights

• Machado leads the Padres in home runs (21), runs batted in (78) and has recorded a team-best batting average of .292.
• Machado is 43rd in home runs and 20th in RBI among all hitters in MLB.
• Fernando Tatis Jr. has 25 doubles, two triples, 17 home runs and 79 walks while batting .264.
• Tatis ranks 77th in homers and 110th in RBI among all major league hitters this year.
• Luis Arraez is batting .285 with 28 doubles, four triples, six home runs and 26 walks.
• Xander Bogaerts has 29 doubles, 10 home runs and 48 walks while batting .262.

Padres Team Props

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FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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