Mariners vs. Cubs Prediction, Odds, Picks - June 22

The Chicago Cubs will look to Ian Happ for continued offensive production when they take on Julio Rodriguez and the Seattle Mariners on Sunday, in the final game of a three-game series at Wrigley Field. The Mariners are favored in this one, at -128, while the underdog Cubs have +107 odds to play spoiler. Seattle is favored on the run line (-1.5). The over/under for the matchup has been set at 11.5 runs.

Here's everything you need from a betting perspective on the Mariners-Cubs game, regarding the run line, moneyline and total, plus expert picks.

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Mariners vs. Cubs Highlights | MLB on FOX

Check out the best highlights between the Seattle Mariners and Chicago Cubs.

Mariners vs. Cubs Game Information & Odds

• When: Sunday, June 22, 2025 at 2:20 p.m. ET
• Where: Wrigley Field in Chicago, Illinois
• How to watch on TV: MARQ and ROOT Sports NW

Mariners vs. Cubs Prediction

• Score Prediction: Cubs 5, Mariners 4
• Total Prediction: Under 11.5 runs
• Win Probabilities: Mariners 56%, Cubs 44%

Mariners vs. Cubs Betting Insights

• This season, the Mariners have been favored 47 times and won 24, or 51.1%, of those games.
• This season Seattle has won 19 of its 37 games, or 51.4%, when favored by at least -128 on the moneyline.
• Bookmakers have implied with the moneyline set for this matchup that the Mariners have a 56.1% chance to win.
• The Cubs have come away with nine wins in the 23 contests they have been listed as the underdogs in this season.
• This season, Chicago has come away with a win three times in 12 chances when named as an underdog of at least +107 or worse on the moneyline.
• The moneyline set for this matchup implies the Cubs have a 48.3% chance of coming away with a victory in the contest.

Mariners Recent Betting Performance

• The Mariners played as the moneyline favorite in five of their last 10 games, and finished 4-1 in those matchups.
• Over their last 10 outings -- all had a set run total -- the Mariners and their opponents combined to go over the total five times.
• The Mariners have gone 4-6-0 against the spread over their past 10 games.

Mariners Recent Stats

Mariners Player Insights

• Cal Raleigh has put up a team-high 30 home runs and 64 runs batted in.
• Raleigh's home runs put him first in the majors, and he ranks second in RBI.
• Raleigh carries a four-game hitting streak into this matchup. During his last five outings he is hitting .381 with two doubles, four home runs, a walk and 10 RBIs.
• Rodriguez has 10 doubles, three triples, 10 home runs and 22 walks while hitting .253.
• Including all MLB hitters, Rodriguez is 69th in homers and 87th in RBI.
• Rodriguez carries a two-game streak with at least one hit into this contest. During his last five outings he is hitting .150 with a double and two walks.
• J.P. Crawford has put up a team-best batting average of .290.
• Jorge Polanco is hitting .258 with nine doubles, 11 home runs and 14 walks.

Mariners Team Props

Cubs Recent Betting Performance

• Over the past 10 games, the Cubs have been underdogs just once and lost that contest.
• The Cubs and their opponents have combined to hit the over four times in their last 10 games with a total.
• The Cubs have four wins against the spread in their last 10 chances.

Cubs Recent Stats

Cubs Player Insights

• Kyle Tucker is hitting .283 with 16 doubles, four triples, 14 home runs and 51 walks.
• Tucker's home run total places him 29th in the majors, and he is 32nd in RBI.
• Pete Crow-Armstrong has been a reliable source of runs this year, leading the lineup with 21 home runs and 61 runs batted in.
• Crow-Armstrong ranks sixth overall in home runs and fourth in RBI this year.
• Seiya Suzuki has a team-high 61 runs batted in.
• Nico Hoerner leads the Cubs with a .284 batting average.

Cubs Team Props

Mariners vs. Cubs Highlights | MLB on FOX

Check out the best highlights between the Seattle Mariners and Chicago Cubs.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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