Guardians vs. White Sox Prediction, Odds, Picks - September 12

The Chicago White Sox and Miguel Vargas hit the field at Progressive Field against Steven Kwan and the Cleveland Guardians on Friday. The Guardians are favored in this one, at -142, while the underdog White Sox have +120 odds to play spoiler. Cleveland (-1.5) is favored on the run line. A 7.5-run total is listed for this contest.

Here's everything you need from a betting perspective on the Guardians-White Sox game, regarding the run line, moneyline and total, plus expert picks.

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Royals vs. Guardians Highlights | MLB on FOX

Enjoy the best moments between Kansas City Royals and the Cleveland Guardians.

Guardians vs. White Sox Game Information & Odds

• When: Friday, September 12, 2025 at 7:10 p.m. ET
• Where: Progressive Field in Cleveland, Ohio
• How to watch on TV: CLEG and CHSN

Guardians vs. White Sox Prediction

• Score Prediction: Guardians 5, White Sox 4
• Total Prediction: Over 7.5 runs
• Win Probabilities: Guardians 54%, White Sox 46%

Guardians vs. White Sox Betting Insights

• This season, the Guardians have been favored 61 times and won 37, or 60.7%, of those games.
• Cleveland has a record of 10-5 in games when bookmakers favor them by at least -142 on the moneyline.
• The moneyline for this contest implies a 58.7% chance of a victory for the Guardians.
• The White Sox have won in 56, or 38.6%, of the 145 contests they have been named as odds-on underdogs this year.
• This year, Chicago has won 39 of 110 games when listed as at least +120 or worse on the moneyline.
• The moneyline set for this matchup implies the White Sox have a 45.5% chance of coming away with a victory in the contest.

Guardians Recent Betting Performance

• The Guardians went 3-1 over the four games they were favored on the moneyline in their last 10 matchups.
• In their last 10 outings (all had set totals), the Guardians combined with their opponents to hit the over on the total three times.
• The Guardians' ATS record is 7-3-0 over their past 10 games.

Guardians Recent Stats

Guardians Player Insights

• Jose Ramirez has racked up a team-best batting average of .285, while pacing the Guardians in home runs (28) and runs batted in (77).
• Including all MLB hitters, Ramirez ranks 17th in batting average, 23rd in on-base percentage, and 16th in slugging.
• Kwan has 26 doubles, a triple, 10 home runs and 50 walks while batting .276.
• Kwan is 189th in home runs and 167th in RBI among all MLB hitters this year.
• Kwan has two games in a row with at least one hit. In his last five games he is hitting .300 with a double, three walks and an RBI.
• Kyle Manzardo is hitting .240 with 15 doubles, two triples, 26 home runs and 46 walks.
• Manzardo is on a four-game hitting streak entering this contest. During his last five outings he is batting .375 with a double, a home run, three walks and four RBIs.
• Angel Martinez has 21 doubles, a triple, 10 home runs and 18 walks while hitting .225.

Guardians Team Props

White Sox Recent Betting Performance

• The White Sox have played as underdogs in 10 of their past 10 games and won eight of those contests.
• In their last 10 games with a total, the White Sox and their opponents are 7-3-0 when it comes to hitting the over.
• The White Sox have nine wins against the spread in their last 10 chances.

White Sox Recent Stats

White Sox Player Insights

• Vargas is batting .233 with 30 doubles, two triples, 14 home runs and 50 walks.
• In all of the majors, Vargas is 140th in homers and 140th in RBI.
• Andrew Benintendi has 16 doubles, two triples, 19 home runs and 37 walks while hitting .248.
• Benintendi is currently 76th in home runs and 104th in RBI in the major leagues.
• Lenyn Sosa paces the White Sox with 20 home runs and 67 runs batted in, while recording a club-best batting average of .265.
• Chase Meidroth is batting .269 with 15 doubles, four home runs and 43 walks.

White Sox Team Props

Royals vs. Guardians Highlights | MLB on FOX

Enjoy the best moments between Kansas City Royals and the Cleveland Guardians.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Cleveland Guardians

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