Guardians vs. White Sox Prediction, Odds, Picks - August 8

Jose Ramirez and the Cleveland Guardians play Luis Robert and the Chicago White Sox at Rate Field on Friday. First pitch is at 7:40 p.m. ET. The Guardians are -134 moneyline favorites for this matchup against the White Sox (+113). Cleveland is the run-line favorite (-1.5). The game's over/under has been set at 8 runs.

Check out everything you need to know from a betting perspective on the Guardians-White Sox game, regarding the run line, moneyline and total, plus expert picks.

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Guardians vs. White Sox Game Information & Odds

• When: Friday, August 8, 2025 at 7:40 p.m. ET
• Where: Rate Field in Chicago, Illinois
• How to watch on TV: CHSN and CLEG

Guardians vs. White Sox Prediction

• Score Prediction: White Sox 5, Guardians 4
• Total Prediction: Over 8 runs
• Win Probabilities: Guardians 52%, White Sox 48%

Guardians vs. White Sox Betting Insights

• This season, the Guardians have been favored 47 times and won 29, or 61.7%, of those games.
• Cleveland has a record of 16-7 in games when bookmakers favor them by at least -134 on the moneyline.
• The sportsbooks' moneyline implies a 57.3% chance of a victory for the Guardians.
• The White Sox have come away with 41 wins in the 113 contests they have been listed as the underdogs in this season.
• Chicago has a win-loss record of 39-64 when favored by +113 or worse by oddsmakers this year.
• The White Sox have an implied victory probability of 46.9% according to the moneyline set for this matchup.

Guardians Recent Betting Performance

• The Guardians were the moneyline favorite in six of their last 10 games, and they finished 4-2 in those matchups.
• Over their last 10 matchups, the Guardians and their opponents combined to hit the over on the run total five times (all 10 games had set totals).
• The Guardians' record against the spread is 5-5-0 over their past 10 games.

Guardians Recent Stats

Guardians Player Insights

• Ramirez has put up a team-best batting average of .296, while leading the Guardians in home runs (23) and runs batted in (61).
• Ramirez's home runs put him 16th in MLB, and he is 48th in RBI.
• Steven Kwan has 20 doubles, a triple, nine home runs and 40 walks while hitting .284.
• Kwan ranks 167th in homers and 161st in RBI among all batters in the majors.
• Kwan enters this matchup looking for his fourth game in a row with a hit. During his last five outings he is hitting .227 with an RBI.
• Carlos Santana is hitting .227 with eight doubles, 11 home runs and 48 walks.
• Kyle Manzardo is hitting .235 with 13 doubles, two triples, 18 home runs and 33 walks.

Guardians Team Props

White Sox Recent Betting Performance

• In 10 games over the last 10 matchups when set as underdogs by sportsbooks, the White Sox had a record of 4-6.
• In their last 10 games with a total, the White Sox and their opponents have failed to hit the over five times.
• The White Sox have six wins against the spread in their last 10 chances.

White Sox Recent Stats

White Sox Player Insights

• Andrew Benintendi has racked up a team-best 14 home runs.
• In all of MLB, Benintendi is 93rd in homers and 121st in RBI.
• Robert has put up 46 runs batted in to lead his team.
• Robert is 118th overall in home runs and 107th in RBI this year.
• Lenyn Sosa has accumulated a team-high batting average of .277.
• Mike Tauchman is batting .279 with 13 doubles, a triple, eight home runs and 30 walks.

White Sox Team Props

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FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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