Guardians vs. Royals Prediction, Odds, Picks - September 11

Jose Ramirez and the Cleveland Guardians head into the final of a four-game series against Maikel Garcia and the Kansas City Royals at Progressive Field, Thursday at 7:15 p.m. ET. The favored Guardians have -140 moneyline odds to win against the underdog Royals, who are listed at +118. Cleveland is the favorite on the run line (-1.5). The total is 7.5 runs for this contest.

Here is everything you need to know from a betting perspective on the Guardians-Royals game, regarding the run line, moneyline and total, plus expert picks.

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Royals vs. Guardians Highlights | MLB on FOX

Enjoy the best moments between Kansas City Royals and the Cleveland Guardians.

Guardians vs. Royals Game Information & Odds

• When: Thursday, September 11, 2025 at 7:15 p.m. ET
• Where: Progressive Field in Cleveland, Ohio
• How to watch on TV: FOX

Guardians vs. Royals Prediction

• Score Prediction: Guardians 5, Royals 4
• Total Prediction: Over 7.5 runs
• Win Probabilities: Guardians 52%, Royals 48%

Guardians vs. Royals Betting Insights

• The Guardians have entered the game as favorites 60 times this season and won 36, or 60%, of those games.
• Cleveland has a record of 11-5 in games when oddsmakers favor them by at least -140 on the moneyline.
• The implied probability of a win from the Guardians, based on the moneyline, is 58.3%.
• The Royals have been underdogs in 82 games this season and have come away with the win 38 times (46.3%) in those contests.
• This season, Kansas City has been victorious 18 times in 37 chances when named as an underdog of at least +118 or longer on the moneyline.
• The moneyline set for this matchup implies the Royals have a 45.9% chance of walking away with the win.

Guardians Recent Betting Performance

• The Guardians were the moneyline favorite for three of their last 10 games, and they went 2-1 in those matchups.
• Over their last 10 matchups, the Guardians and their opponents combined to go over the run total four times (all 10 of the games had set totals).
• The Guardians are 7-3-0 against the spread over their past 10 games.

Guardians Recent Stats

Guardians Player Insights

• Not only does Ramirez lead the Guardians in hitting with his .287 average, he also is their foremost power hitter with 28 home runs and 76 RBI.
• Among all hitters in the majors, Ramirez is 21st in homers and 45th in RBI.
• Ramirez has collected a hit in seven games in a row. In his last 10 outings he is batting .342 with four doubles, a triple, two home runs, three walks and eight RBIs.
• Steven Kwan has 25 doubles, a triple, 10 home runs and 50 walks while hitting .276.
• Kwan is 187th in home runs and 164th in RBI among all MLB hitters this season.
• Kyle Manzardo is hitting .240 with 15 doubles, two triples, 26 home runs and 46 walks.
• Manzardo will look to build on his three-game hitting in this matchup. In his last five games he is hitting .400 with a double, two home runs, four walks and five RBIs.
• Angel Martinez is hitting .225 with 21 doubles, a triple, 10 home runs and 18 walks.

Guardians Team Props

Royals Recent Betting Performance

• In five games as underdogs over the last 10 matchups, the Royals have a record of 2-3.
• In their last 10 games with a total, the Royals and their opponents are 2-8-0 when it comes to hitting the over.
• The Royals have one win against the spread in their last 10 chances.

Royals Recent Stats

Royals Player Insights

• Bobby Witt Jr. paces the Royals with a team-high batting average of .295.
• In all of the majors, Witt ranks 60th in homers and 42nd in RBI.
• Garcia has 36 doubles, five triples, 16 home runs and 54 walks while batting .292.
• Garcia is 110th in homers and 72nd in RBI among all MLB hitters this season.
• Vinnie Pasquantino has been solid source of run production for the Royals with 29 long balls and 100 runs batted in.
• Salvador Perez has 34 doubles, 25 home runs and 23 walks while hitting .235.

Royals Team Props

Royals vs. Guardians Highlights | MLB on FOX

Enjoy the best moments between Kansas City Royals and the Cleveland Guardians.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Cleveland Guardians

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