Guardians vs. Reds Prediction, Odds, Picks - June 10

Jose Ramirez and the Cleveland Guardians meet Christian Encarnacion-Strand and the Cincinnati Reds at Progressive Field on Tuesday at 6:40 p.m. ET, in the second game of a three-game series. The Guardians are the favorite in this one, at -110, while the underdog Reds have -109 odds to upset. Cincinnati (-1.5) is favored on the run line. The total for the contest has been listed at 8.5 runs.

Check out everything you need from a betting perspective on the Guardians-Reds game, regarding the run line, moneyline and total, plus expert picks.

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Reds vs. Guardians Highlights | MLB on FOX

Check out the top moments from this MLB game between the Cincinnati Reds and the Cleveland Guardians!

Guardians vs. Reds Game Information & Odds

• When: Tuesday, June 10, 2025 at 6:40 p.m. ET
• Where: Progressive Field in Cleveland, Ohio
• How to watch on TV: CLEG and FDSOH

Guardians vs. Reds Prediction

• Score Prediction: Guardians 5, Reds 4
• Total Prediction: Under 8.5 runs
• Win Probabilities: Guardians 52%, Reds 48%

Guardians vs. Reds Betting Insights

• This season, the Guardians have won 15 out of the 24 games, or 62.5%, in which they've been favored.
• This season Cleveland has won 15 of its 24 games, or 62.5%, when favored by at least -110 on the moneyline.
• The implied probability of a win from the Guardians, based on the moneyline, is 52.4%.
• The Reds have come away with 19 wins in the 37 contests they have been listed as the underdogs in this season.
• Cincinnati has a win-loss record of 19-17 when favored by -109 or worse by sportsbooks this year.
• The Reds have an implied victory probability of 52.2% according to the moneyline set for this matchup.

Guardians Recent Betting Performance

• The Guardians were the moneyline favorite for five of their last 10 games, and finished 3-2 in those matchups.
• Over their last 10 outings, the Guardians and their opponents combined to go over the run total three times (all 10 games had set totals).
• The Guardians' record against the spread is 5-5-0 over their past 10 games.

Guardians Recent Stats

Guardians Player Insights

• Ramirez paces the Guardians with 12 home runs and 32 runs batted in, while accumulating a team-high batting average of .333.
• Ramirez ranks 29th in homers and 67th in RBI among all hitters in the majors.
• Ramirez carries a nine-game hitting streak into this matchup. During his last 10 games he is batting .389 with a double, three home runs, seven walks and five RBIs.
• Steven Kwan is hitting .309 with 14 doubles, five home runs and 22 walks.
• Of all major league hitters, Kwan is 159th in home runs and 151st in RBI.
• Carlos Santana has six doubles, seven home runs and 32 walks while batting .256.
• Santana is on a two-game hitting streak entering this contest. In his last five games he is hitting .188 with a walk and an RBI.
• Kyle Manzardo is batting .203 with six doubles, two triples, 11 home runs and 23 walks.

Guardians Team Props

Reds Recent Betting Performance

• In seven games over the last 10 matchups when set as underdogs by bookmakers, the Reds had a record of 4-3.
• In their last 10 games with a total, the Reds and their opponents have combined to hit the over four times.
• The Reds have a record of 6-4-0 ATS over their last 10 games.

Reds Recent Stats

Reds Player Insights

• Elly De La Cruz paces the Reds with 12 home runs and runs batted in, driving in 43.
• Among all batters in the big leagues, De La Cruz's home run total is 29th and his RBI tally ranks 17th.
• TJ Friedl is hitting .295 to lead the lineup.
• Friedl is 130th overall in homers and 130th in RBI this year.
• Gavin Lux has 14 doubles, a triple, two home runs and 27 walks while batting .281.
• Jose Trevino is hitting .304 with 14 doubles, four home runs and seven walks.

Reds Team Props

Reds vs. Guardians Highlights | MLB on FOX

Check out the top moments from this MLB game between the Cincinnati Reds and the Cleveland Guardians!

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Cleveland Guardians

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