Guardians vs. Orioles Prediction, Odds, Picks - July 24

The Cleveland Guardians and Baltimore Orioles will play on Thursday at Progressive Field, at 1:10 p.m. ET, with Steven Kwan and Ryan O'Hearn among those expected to produce at the plate. The Guardians are favored in this one, at -119, while the underdog Orioles have -100 odds to play spoiler. Baltimore is the run-line favorite (-1.5). The contest's over/under has been set at 9 runs.

Here is everything you need from a betting perspective on the Guardians-Orioles game, regarding the run line, moneyline and total, plus expert picks.

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Orioles vs. Guardians Highlights | MLB on FOX

Check out the best moments between the Baltimore Orioles and the Cleveland Guardians.

Guardians vs. Orioles Game Information & Odds

• When: Thursday, July 24, 2025 at 1:10 p.m. ET
• Where: Progressive Field in Cleveland, Ohio
• How to watch on TV: MLB Network, CLEG, and MASN

Guardians vs. Orioles Prediction

• Score Prediction: Guardians 5, Orioles 4
• Total Prediction: Over 9 runs
• Win Probabilities: Guardians 55%, Orioles 45%

Guardians vs. Orioles Betting Insights

• The Guardians have won 25, or 62.5%, of the 40 games they've played as favorites this season.
• Cleveland has a record of 20-11 in games when oddsmakers favor them by at least -119 on the moneyline.
• Oddsmakers have implied with the moneyline set for this matchup that the Guardians have a 54.3% chance to win.
• The Orioles have been victorious in 21, or 42%, of the 50 contests they have been chosen as underdogs in this season.
• This season, Baltimore has come away with a win 17 times in 41 chances when named as an underdog of at least -100 or worse on the moneyline.
• The moneyline set for this matchup implies the Orioles have a 50% chance of walking away with the win.

Guardians Recent Betting Performance

• The Guardians played as the moneyline favorite in nine of their last 10 games, and finished 7-2 in those matchups.
• In their last 10 matchups, the Guardians and their opponents combined to hit the over seven times (all 10 of the games had set totals).
• The Guardians' record against the spread is 6-4-0 over their past 10 games.

Guardians Recent Stats

Guardians Player Insights

• Not only does Jose Ramirez lead the Guardians in hitting with his .294 average, he also is their premier power option with 21 home runs and 56 RBI.
• Among all hitters in the majors, Ramirez is 16th in homers and 43rd in RBI.
• Ramirez brings a hitting streak of three games into this game. During his last five outings he is hitting .222 with a double, three home runs, five walks and six RBIs.
• Kwan is batting .285 with 20 doubles, a triple, six home runs and 37 walks.
• Kwan is 205th in home runs and 169th in RBI in the majors.
• Carlos Santana is batting .226 with seven doubles, 11 home runs and 45 walks.
• Kyle Manzardo is hitting .221 with 12 doubles, two triples, 16 home runs and 29 walks.
• Manzardo has recorded at least one hit in three games in a row. In his last five games he is hitting .294 with a double, two home runs, a walk and eight RBIs.

Guardians Team Props

Orioles Recent Betting Performance

• The Orioles have played as underdogs in seven of their past 10 games and won two of those contests.
• In their last 10 games with a total, the Orioles and their opponents are 4-6-0 when it comes to hitting the over.
• The Orioles have a record of 5-5-0 ATS over their last 10 games.

Orioles Recent Stats

Orioles Player Insights

• Gunnar Henderson is batting .275 with 22 doubles, four triples, 11 home runs and 35 walks.
• Henderson is 113th in homers and 151st in RBI among all batters in MLB.
• O'Hearn's .281 batting average is a team-high mark.
• O'Hearn ranks 101st among all batters in the big leagues in home runs, and 139th in RBI.
• Jackson Holliday has 14 home runs, tops in the clubhouse.
• Cedric Mullins has collected a team-leading 42 runs batted in.

Orioles Team Props

Orioles vs. Guardians Highlights | MLB on FOX

Check out the best moments between the Baltimore Orioles and the Cleveland Guardians.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Cleveland Guardians

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