Guardians vs. Athletics Prediction, Odds, Picks - June 21

Luis Ortiz will start for the Cleveland Guardians on Saturday at Sutter Health Park against Nick Kurtz and the Athletics. First pitch is at 10:05 p.m. ET for the second game of a three-game series. The Guardians are favored in this one, at -135, while the underdog Athletics have +113 odds to upset. The Guardians are a 1.5-run favorite (at +118 odds). The matchup's over/under has been listed at 9.5 runs.

Here's everything you need to know from a betting perspective on the Guardians-Athletics game, regarding the run line, moneyline and total, plus expert picks.

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Athletics vs. Blue Jays Highlights | MLB on FOX

Check out the best moments between the Oakland Athletics and the Toronto Blue Jays game 1.

Guardians vs. Athletics Game Information & Odds

• When: Saturday, June 21, 2025 at 10:05 p.m. ET
• Where: Sutter Health Park in West Sacramento, California
• How to watch on TV: NBCS-CA and CLEG

Guardians vs. Athletics Prediction

• Score Prediction: Guardians 4, Athletics 3
• Total Prediction: Under 9.5 runs
• Win Probabilities: Guardians 51%, Athletics 49%

Guardians vs. Athletics Betting Insights

• The Guardians have been favorites in 26 games this season and won 15 (57.7%) of those contests.
• This season, the Guardians have won seven of their 10 games, or 70%, when favored by at least -135 on the moneyline.
• The moneyline for this contest implies a 57.4% chance of a victory for the Guardians.
• The Athletics have won in 23, or 38.3%, of the 60 contests they have been named as odds-on underdogs this year.
• This season, the Athletics have come away with a win 14 times in 46 chances when named as an underdog of at least +113 or longer on the moneyline.
• The moneyline set for this matchup implies the Athletics have a 46.9% chance of walking away with the win.

Guardians Recent Betting Performance

• Over the last 10 games, the Guardians were favored on the moneyline three times, but they lost every matchup.
• In their last 10 outings, the Guardians and their opponents combined to go over the total three times (all 10 games had set totals).
• The Guardians have gone 6-4-0 against the spread over their past 10 games.

Guardians Recent Stats

Guardians Player Insights

• Jose Ramirez provides the Guardians with a shot of both power and average, leading the team in homers with 13 and hitting at .317. He has also driven in 35 runs this season.
• Of all batters in the majors, Ramirez is 33rd in home runs and 79th in RBI.
• Ramirez takes a hitting streak of three games into this game. In his last five games he is batting .158 with a double, a walk and an RBI.
• Steven Kwan has 15 doubles, six home runs and 25 walks while hitting .299.
• Kwan is 162nd in home runs and 179th in RBI on the season.
• Kwan heads into this game looking for his third game in a row with a hit. In his last five games he is batting .250 with a double and two walks.
• Carlos Santana has a team-high 36 runs batted in.
• Kyle Manzardo has 10 doubles, two triples, 11 home runs and 24 walks while batting .212.

Guardians Team Props

Athletics Recent Betting Performance

• The Athletics have played as underdogs in 10 of their past 10 games and have gone 6-4 in those contests.
• The Athletics and their opponents have combined to hit the over four times in their last 10 games with a total.
• The Athletics have won eight of their last 10 games against the spread.

Athletics Recent Stats

Athletics Player Insights

• Jacob Wilson leads the Athletics with a team-high batting average of .358.
• Wilson ranks 91st in home runs and 46th in RBI among all batters in the big leagues.
• Wilson carries a three-game hitting streak into this matchup. In his last five games he is batting .222 with a home run, two walks and two RBIs.
• Brent Rooker has shown his power as he paces his team with 15 home runs.
• Rooker is currently 19th in homers and 40th in RBI in the big leagues.
• Tyler Soderstrom has put up a team-high 45 runs batted in.
• Lawrence Butler has 23 doubles, a triple, 11 home runs and 27 walks while hitting .264.

Athletics Team Props

Athletics vs. Blue Jays Highlights | MLB on FOX

Check out the best moments between the Oakland Athletics and the Toronto Blue Jays game 1.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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