Giants vs. White Sox Prediction, Odds, Picks - June 27

Jung Hoo Lee and the San Francisco Giants square off against the Chicago White Sox and starter Aaron Civale on Friday at 7:40 p.m. ET at Rate Field. The favored Giants have -159 moneyline odds to win against the underdog White Sox, who are listed at +133. San Francisco (-1.5) is the favorite on the run line. A 9-run over/under has been set in the game.

Here's everything you need to know from a betting perspective on the Giants-White Sox game, regarding the run line, moneyline and total, plus expert picks.

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Giants vs. White Sox Game Information & Odds

• When: Friday, June 27, 2025 at 7:40 p.m. ET
• Where: Rate Field in Chicago, Illinois
• How to watch on TV: CHSN and NBCS-BA

Giants vs. White Sox Prediction

• Score Prediction: Giants 5, White Sox 4
• Total Prediction: Over 9 runs
• Win Probabilities: Giants 52%, White Sox 48%

Giants vs. White Sox Betting Insights

• The Giants have been favorites in 52 games this season and won 29 (55.8%) of those contests.
• San Francisco has a record of 11-10, a 52.4% win rate, when favored by -159 or more by bookmakers this season.
• Sportsbooks have implied with the moneyline set for this matchup that the Giants have a 61.4% chance to win.
• The White Sox have won in 26, or 32.1%, of the 81 contests they have been named as odds-on underdogs this year.
• This year, Chicago has won 21 of 64 games when listed as at least +133 or worse on the moneyline.
• The White Sox have an implied victory probability of 42.9% according to the moneyline set by sportsbooks for this matchup.

Giants Recent Betting Performance

• The Giants went 3-6 across the nine games they were favored on the moneyline in their last 10 matchups.
• Over their last 10 outings (all 10 of them had set totals), the Giants and their opponents combined to hit the over four times.
• The Giants' ATS record is 2-8-0 over their past 10 games.

Giants Recent Stats

Giants Player Insights

• Rafael Devers leads the Giants in home runs (17) and runs batted in (63).
• In all of the majors, Devers ranks 15th in homers and fifth in RBI.
• Jung Hoo Lee is batting .252 with 17 doubles, six triples, six home runs and 29 walks.
• Lee is 169th in homers in the majors, and 97th in RBI.
• Heliot Ramos has racked up a team-high batting average of .283.
• Wilmer Flores is batting .243 with seven doubles, 11 home runs and 25 walks.

Giants Team Props

White Sox Recent Betting Performance

• The White Sox have played as underdogs in 10 of their past 10 games and won three of those contests.
• When it comes to hitting the over, the White Sox and their opponents are 4-4-2 in their last 10 games with a total.
• Over their last 10 games, the White Sox are 5-5-0 against the spread.

White Sox Recent Stats

White Sox Player Insights

• Miguel Vargas leads the White Sox with 10 home runs and 34 runs batted in, while recording a team-best batting average of .233.
• In all of the big leagues, Vargas ranks 84th in home runs and 97th in RBI.
• Andrew Benintendi has nine doubles, two triples, nine home runs and 16 walks while batting .236.
• Benintendi is 97th overall in home runs and 123rd in RBI this season.
• Chase Meidroth is hitting .264 with five doubles, two home runs and 27 walks.
• Luis Robert is hitting .185 with eight doubles, eight home runs and 29 walks.

White Sox Team Props

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FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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