Giants vs. Rockies Prediction, Odds, Picks - September 26

Trevor McDonald takes the mound for the San Francisco Giants on Friday at Oracle Park against Hunter Goodman and the Colorado Rockies. First pitch is at 10:15 p.m. ET for the first game of a three-game series. The Giants are listed as -246 moneyline favorites in this matchup with the Rockies (+200). San Francisco is the favorite on the run line (-1.5). The matchup's total is listed at 8.5 runs.

Take a look at everything you need to know from a betting perspective on the Giants-Rockies game, regarding the run line, moneyline and total, plus expert picks.

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Giants vs. Rockies Game Information & Odds

• When: Friday, September 26, 2025 at 10:15 p.m. ET
• Where: Oracle Park in San Francisco, California
• How to watch on TV: NBCS-BA and COLR

Giants vs. Rockies Prediction

• Score Prediction: Giants 4, Rockies 2
• Total Prediction: Under 8.5 runs
• Win Probabilities: Giants 69%, Rockies 31%

Giants vs. Rockies Betting Insights

• The Giants have entered the game as favorites 89 times this season and won 46, or 51.7%, of those games.
• This season San Francisco has won three of its four games when favored by at least -246 on the moneyline.
• The Giants have a 71.1% chance to win this game based on the implied probability of the moneyline.
• The Rockies have won in 41, or 26.6%, of the 154 contests they have been named as odds-on underdogs this year.
• This season, Colorado has come away with a win 14 times in 73 chances when named as an underdog of at least +200 or worse on the moneyline.
• The Rockies have an implied victory probability of 33.3% according to the moneyline set for this matchup.

Giants Recent Betting Performance

• In the last 10 games, the Giants were listed as the moneyline favorite by oddsmakers only twice, and they lost both games.
• In their last 10 matchups, the Giants and their opponents combined to go over the run total four times (all 10 of the games had set totals).
• The Giants have put together a 5-5-0 record against the spread over their past 10 games.

Giants Recent Stats

Giants Player Insights

• Rafael Devers is the Giants best power hitter, crushing 34 long balls this season in addition to collecting 107 RBI, both team highs.
• Among all hitters in MLB, Devers is 13th in home runs and ninth in RBI.
• Devers takes a hitting streak of five games into this matchup. In his last five games he is batting .250 with three home runs, three walks and three RBIs.
• Jung Hoo Lee has a club-best .260 batting average.
• Lee ranks 247th in homers and 149th in RBI among all batters in baseball.
• Lee heads into this game looking for his third game in a row with a hit. During his last five outings he is hitting .211 with a double, a walk and an RBI.
• Willy Adames is batting .225 with 22 doubles, two triples, 28 home runs and 79 walks.
• Adames is on a two-game hitting streak entering this contest. During his last five outings he is batting .200 with a double, three walks and two RBIs.
• Heliot Ramos has 24 doubles, a triple, 20 home runs and 51 walks while batting .258.
• Ramos is riding a three-game hitting streak into this one. During his last five outings he is batting .292 with two home runs and four RBIs.

Giants Team Props

Rockies Recent Betting Performance

• In nine games as underdogs over the last 10 matchups, the Rockies have a record of 1-8.
• The Rockies and their opponents have combined to hit the over seven times in their last 10 games with a total.
• The Rockies have a record of 4-6-0 ATS over their last 10 games.

Rockies Recent Stats

Rockies Player Insights

• Goodman leads the squad with a batting average of .278, and leads the Rockies in home runs, with 30 and runs batted in with 90.
• Goodman's home run total puts him 25th in MLB, and he is 29th in RBI.
• Mickey Moniak is hitting .270 with 20 doubles, eight triples, 24 home runs and 22 walks.
• Moniak is 53rd in homers and 90th in RBI among all MLB hitters this season.
• Jordan Beck has 27 doubles, five triples, 15 home runs and 43 walks while hitting .262.
• Tyler Freeman is batting .281 with 20 doubles, two triples, two home runs and 34 walks.

Rockies Team Props

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Enjoy the best moments between the Colorado Rockies and the Seattle Mariners.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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San Francisco Giants

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