Giants vs. Athletics Prediction, Odds, Picks - May 16

JP Sears takes the mound for the Athletics on Friday at Oracle Park against Jung Hoo Lee and the San Francisco Giants. First pitch is at 10:15 p.m. ET. Oddsmakers list the Giants as -199 favorites on the moneyline, while giving the underdog Athletics +165 moneyline odds to win. The Giants are a 1.5-run favorite (at +116 odds). The over/under is 7 runs for this game.

Check out everything you need to know from a betting perspective on the Giants-Athletics game, regarding the run line, moneyline and total, plus expert picks.

Keep up with MLB on FOX Sports.

Diamondbacks vs. Giants Highlights | MLB on FOX

Check out the best moments between the Arizona Diamondbacks and the San Francisco Giants.

Giants vs. Athletics Game Information & Odds

• When: Friday, May 16, 2025 at 10:15 p.m. ET
• Where: Oracle Park in San Francisco, California
• How to watch on TV: MLB Network, NBCS-BA, and NBCS-CA

Giants vs. Athletics Prediction

• Score Prediction: Giants 4, Athletics 3
• Total Prediction: Over 7 runs
• Win Probabilities: Giants 59%, Athletics 41%

Giants vs. Athletics Betting Insights

• This season, the Giants have been favored 24 times and won 15, or 62.5%, of those games.
• This season, the Giants have won three of their four games when favored by at least -199 on the moneyline.
• The implied probability of a win from the Giants, based on the moneyline, is 66.6%.
• The Athletics have won in 13, or 43.3%, of the 30 contests they have been named as odds-on underdogs this year.
• This season, the Athletics have come away with a win one time in four chances when named as an underdog of at least +165 or worse on the moneyline.
• The moneyline set for this matchup implies the Athletics have a 37.7% chance of walking away with the win.

Giants Recent Betting Performance

• The Giants went 1-2 across the three games they were a moneyline favorite in their last 10 matchups.
• In their last 10 outings (all had set totals), the Giants combined with their opponents to hit the over on the total six times.
• The Giants' ATS record is 7-3-0 over their past 10 games.

Giants Recent Stats

Giants Player Insights

• Lee is batting .286 with 11 doubles, two triples, six home runs and 11 walks.
• In all of the majors, Lee ranks 67th in home runs and 18th in RBI.
• Lee brings a hitting streak of four games into this game. In his last five games he is hitting .238 with two home runs and six RBIs.
• Heliot Ramos has a club-best .288 batting average.
• Ramos ranks 48th in homers and 66th in RBI among all hitters in the majors.
• Matt Chapman paces the Giants with eight home runs.
• Wilmer Flores' 33 runs batted in pace his team.
• Flores has recorded at least one hit in three games in a row. During his last five outings he is batting .294 with two walks.

Giants Team Props

Athletics Recent Betting Performance

• The Athletics have played as underdogs in eight of their past 10 games and have gone 3-5 in those contests.
• The Athletics and their opponents have combined to hit the over eight times in their last 10 games with a total.
• The Athletics have a record of 4-6-0 ATS over their last 10 games.

Athletics Recent Stats

Athletics Player Insights

• Jacob Wilson leads the Athletics with a .347 batting average.
• In all of the majors, Wilson ranks 98th in home runs and 31st in RBI.
• Tyler Soderstrom has hit 10 home runs with 29 runs batted in, leading the team in both categories.
• Soderstrom is currently 15th in home runs and 18th in RBI in the big leagues.
• Shea Langeliers has six doubles, eight home runs and 14 walks while batting .266.
• Brent Rooker leads the Athletics with 10 home runs.

Athletics Team Props

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

Want great stories delivered right to your inbox? Create or log in to your FOX Sports account, follow leagues, teams and players to receive a personalized newsletter daily.

FOLLOW Follow your favorites to personalize your FOX Sports experience

San Francisco Giants

Athletics