Dodgers vs. Padres Prediction, Odds, Picks - August 22

Shohei Ohtani and Ramon Laureano will look to continue their recent offensive production when the Los Angeles Dodgers and San Diego Padres meet at PETCO Park on Friday, at 9:40 p.m. ET. The Dodgers are -125 moneyline favorites for this matchup with the Padres (+105). Los Angeles (-1.5) is the favorite on the run line. The over/under is 8 runs for this matchup.

Take a look at everything you need to know from a betting perspective on the Dodgers-Padres game, regarding the run line, moneyline and total, plus expert picks.

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Tom Verducci on Brewers dominance, Cubs, "put up or shut up" for Dodgers | FULL INTERVIEW | The Herd

FOX Sports MLB Analyst Tom Verducci joins Danny Parkins to break down the Milwaukee Brewers' dominance and why they're the best team in baseball, along with whether the Chicago Cubs are still dangerous or not. He also explains why it is "put up or shut up" time for the Los Angeles Dodgers and whether there will be more fireworks between the champs and San Diego Padres. Verducci emphasizes the importance of the Boston Red Sox-New York Yankees weekend series for October baseball. He then touches on MLB commissioner Rob Manfred hinting on league expansion and realignment.

Dodgers vs. Padres Game Information & Odds

• When: Friday, August 22, 2025 at 9:40 p.m. ET
• Where: PETCO Park in San Diego, California
• How to watch on TV: SDPA and SportsNet LA

Dodgers vs. Padres Prediction

• Score Prediction: Padres 5, Dodgers 4
• Total Prediction: Over 8 runs
• Win Probabilities: Dodgers 52%, Padres 48%

Dodgers vs. Padres Betting Insights

• The Dodgers have won 66, or 58.9%, of the 112 games they've played as favorites this season.
• Los Angeles has entered 103 games this season favored by -125 or more and is 61-42 in those contests.
• The implied probability of a win from the Dodgers, based on the moneyline, is 55.6%.
• The Padres have been chosen as underdogs in 58 games this year and have walked away with the win 29 times (50%) in those games.
• This season, San Diego has come away with a win 21 times in 46 chances when named as an underdog of at least +105 or longer on the moneyline.
• The Padres have an implied victory probability of 48.8% according to the moneyline set by sportsbooks for this matchup.

Dodgers Recent Betting Performance

• The Dodgers went 5-5 across the 10 games they were moneyline favorites in their last 10 matchups.
• In their last 10 outings (all 10 of them had set totals), the Dodgers and their opponents combined to hit the over six times.
• The Dodgers' ATS record is 3-7-0 over their past 10 games.

Dodgers Recent Stats

Dodgers Player Insights

• Ohtani paces the Dodgers in home runs (44) and runs batted in (83).
• Of all batters in the majors, Ohtani ranks third in home runs and 12th in RBI.
• Ohtani brings a hitting streak of five games into this matchup. In his last five games he is hitting .353 with a double, a home run, four walks and three RBIs.
• Mookie Betts has 17 doubles, a triple, 13 home runs and 48 walks while batting .246.
• Betts ranks 118th in home runs and 83rd in RBI among all hitters in MLB.
• Betts has four straight games with at least one hit. In his last five games he is hitting .316 with a home run, four walks and an RBI.
• Freddie Freeman leads the Dodgers with a .306 batting average.
• Freeman will look to build on his six-game hitting in this matchup. In his last 10 outings he is hitting .282 with three doubles, two home runs, three walks and six RBIs.
• Andy Pages is hitting .274 with 21 doubles, a triple, 21 home runs and 27 walks.

Dodgers Team Props

Padres Recent Betting Performance

• In five games as underdogs over the last 10 matchups, the Padres have a record of 2-3.
• The Padres and their opponents have combined to hit the over four times in their last 10 games with a total.
• Over their last 10 games, the Padres are 8-2-0 against the spread.

Padres Recent Stats

Padres Player Insights

• Manny Machado leads the Padres in home runs (21), runs batted in (77) and has posted a team-high batting average of .294.
• In all of the majors, Machado is 41st in homers and 20th in RBI.
• Machado has collected a hit in four straight games. In his last five games he is hitting .286 with two doubles, a home run and five RBIs.
• Fernando Tatis Jr. is hitting .268 with 25 doubles, two triples, 17 home runs and 74 walks.
• Tatis is currently 74th in homers and 104th in RBI in the major leagues.
• Luis Arraez is hitting .289 with 27 doubles, four triples, six home runs and 26 walks.
• Xander Bogaerts is hitting .262 with 28 doubles, 10 home runs and 47 walks.

Padres Team Props

Tom Verducci on Brewers dominance, Cubs, "put up or shut up" for Dodgers | FULL INTERVIEW | The Herd

FOX Sports MLB Analyst Tom Verducci joins Danny Parkins to break down the Milwaukee Brewers' dominance and why they're the best team in baseball, along with whether the Chicago Cubs are still dangerous or not. He also explains why it is "put up or shut up" time for the Los Angeles Dodgers and whether there will be more fireworks between the champs and San Diego Padres. Verducci emphasizes the importance of the Boston Red Sox-New York Yankees weekend series for October baseball. He then touches on MLB commissioner Rob Manfred hinting on league expansion and realignment.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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