Dodgers vs. Orioles Prediction, Odds, Picks - September 5

Shohei Ohtani and the Los Angeles Dodgers meet Jackson Holliday and the Baltimore Orioles on Friday at 7:05 p.m. ET. The Dodgers are -169 moneyline favorites in this matchup against the Orioles (+142). Los Angeles is the favorite on the run line (-1.5 with -106 odds). The over/under is 9 runs for the contest (with -107 odds to go over and -113 odds on the under).

Here is everything you need from a betting perspective on the Dodgers-Orioles game, regarding the run line, moneyline and total, plus expert picks.

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Orioles vs. Giants Highlights | MLB on FOX

Check out the best moments between the Baltimore Orioles and San Francisco Giants.

Dodgers vs. Orioles Game Information & Odds

• When: Friday, September 5, 2025 at 7:05 p.m. ET
• Where: Oriole Park at Camden Yards in Baltimore, Maryland
• How to watch on TV: MASN and SportsNet LA

Dodgers vs. Orioles Prediction

• Score Prediction: Dodgers 6, Orioles 5
• Total Prediction: Over 9 runs
• Win Probabilities: Dodgers 51%, Orioles 49%

Dodgers vs. Orioles Betting Insights

• The Dodgers have won 70, or 56.9%, of the 123 games they've played as favorites this season.
• Los Angeles is 42-32 this season when entering a game favored by -169 or more on the moneyline.
• The implied probability of a win from the Dodgers, based on the moneyline, is 62.8%.
• The Orioles have been victorious in 35, or 45.5%, of the 77 contests they have been chosen as underdogs in this season.
• Baltimore has a win-loss record of 7-9 when favored by +142 or worse by bookmakers this year.
• The Orioles have an implied victory probability of 41.3% according to the moneyline set by oddsmakers for this matchup.

Dodgers Recent Betting Performance

• The Dodgers have a 4-5 record over the nine games they were favored on the moneyline in their last 10 matchups.
• In their last 10 outings -- all had a set run total -- the Dodgers and their opponents combined to hit the over on the total three times.
• The Dodgers have a 4-6-0 record against the spread over their past 10 games.

Dodgers Recent Stats

Dodgers Player Insights

• Ohtani has racked up a team-high 46 home runs and 87 runs batted in.
• In all of MLB, Ohtani is third in homers and 18th in RBI.
• Mookie Betts is batting .250 with 18 doubles, a triple, 15 home runs and 54 walks.
• Of all major league hitters, Betts is 116th in home runs and 91st in RBI.
• Freddie Freeman is batting .294 with 36 doubles, a triple, 18 home runs and 53 walks.
• Andy Pages is batting .272 with 22 doubles, a triple, 24 home runs and 27 walks.

Dodgers Team Props

Orioles Recent Betting Performance

• The Orioles have played as underdogs in nine of their past 10 games and have gone 3-6 in those contests.
• When it comes to hitting the over, the Orioles and their opponents are 4-5-1 in their last 10 games with a total.
• The Orioles have won seven of their last 10 games against the spread.

Orioles Recent Stats

Orioles Player Insights

• Gunnar Henderson paces the Orioles in home runs (16), runs batted in (61) and has recorded a team-high batting average of .278.
• Among all hitters in the big leagues, Henderson ranks 101st in home runs and 91st in RBI.
• Holliday's 16 home runs pace his team.
• Holliday ranks 101st in homers and 133rd in RBI among all MLB batters this season.
• Ryan Mountcastle has 17 doubles, five home runs and 13 walks while batting .266.
• Colton Cowser has 12 doubles, 13 home runs and 17 walks while batting .214.

Orioles Team Props

Orioles vs. Giants Highlights | MLB on FOX

Check out the best moments between the Baltimore Orioles and San Francisco Giants.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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