Dodgers vs. Diamondbacks Prediction, Odds, Picks - September 23

Shohei Ohtani and the Los Angeles Dodgers will play Geraldo Perdomo and the Arizona Diamondbacks on Tuesday at Chase Field, at 9:40 p.m. ET. The favored Dodgers have -164 moneyline odds to win against the underdog Diamondbacks, who are listed at +138. Los Angeles is favored on the run line (-1.5 with -103 odds). The total is 9 runs for the contest (with -109 odds on the over and -111 odds to go under).

Here is everything you need to know from a betting perspective on the Dodgers-Diamondbacks game, regarding the run line, moneyline and total, plus expert picks.

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Dodgers vs. Diamondbacks Game Information & Odds

• When: Tuesday, September 23, 2025 at 9:40 p.m. ET
• Where: Chase Field in Phoenix, Arizona
• How to watch on TV: ARID and SportsNet LA

Dodgers vs. Diamondbacks Prediction

• Score Prediction: Diamondbacks 6, Dodgers 5
• Total Prediction: Over 9 runs
• Win Probabilities: Dodgers 51%, Diamondbacks 49%

Dodgers vs. Diamondbacks Betting Insights

• The Dodgers have entered the game as favorites 138 times this season and won 79, or 57.2%, of those games.
• This season Los Angeles has won 50 of its 87 games, or 57.5%, when favored by at least -164 on the moneyline.
• The Dodgers have a 62.1% chance to win this game based on the implied probability of the moneyline.
• The Diamondbacks have been chosen as underdogs in 66 games this year and have walked away with the win 33 times (50%) in those games.
• Arizona has a win-loss record of 6-6 when favored by +138 or worse by bookmakers this year.
• Oddsmakers have implied with the moneyline set for this matchup that the Diamondbacks have a 42% chance of pulling out a win.

Dodgers Recent Betting Performance

• The Dodgers were the moneyline favorite in nine of their last 10 games, and they went 5-4 in those matchups.
• In their last 10 matchups (all 10 of them had set totals), the Dodgers and their opponents combined to go over the run total five times.
• The Dodgers' record against the spread is 6-4-0 over their past 10 games.

Dodgers Recent Stats

Dodgers Player Insights

• Ohtani leads the Dodgers in home runs (53) and runs batted in (99).
• Among all hitters in the majors, Ohtani's home run total places him second, and his RBI tally puts him 13th.
• Ohtani takes a hitting streak of nine games into this game. During his last 10 games he is batting .325 with three doubles, five home runs, eight walks and seven RBIs.
• Mookie Betts is batting .258 with 23 doubles, two triples, 20 home runs and 60 walks.
• Betts is 76th in home runs in the majors, and 52nd in RBI.
• Freddie Freeman paces the Dodgers with a team-high batting average of .292.
• Freeman is on a two-game hitting streak entering this contest. During his last five outings he is batting .250 with a home run and three RBIs.
• Andy Pages is batting .278 with 27 doubles, a triple, 25 home runs and 28 walks.

Dodgers Team Props

Diamondbacks Recent Betting Performance

• In five games over the last 10 matchups when set as underdogs by sportsbooks, the Diamondbacks had a record of 4-1.
• When it comes to hitting the over, the Diamondbacks and their opponents are 5-4-1 in their last 10 games with a total.
• The Diamondbacks are 7-3-0 ATS over their last 10 games.

Diamondbacks Recent Stats

Diamondbacks Player Insights

• Perdomo has a team-high batting average of .290 while pacing the Diamondbacks in runs batted in with a mark of 97.
• Perdomo's home run total places him 86th in the majors, and he is 14th in RBI.
• Perdomo takes a hitting streak of 11 games into this game. In his last 10 games he is batting .405 with four doubles, a triple, two home runs, seven walks and six RBIs.
• Corbin Carroll has a team-best 31 home runs.
• Carroll is 15th overall in home runs and 33rd in RBI this year.
• Ketel Marte has 26 doubles, 26 home runs and 63 walks while batting .280.
• Gabriel Moreno is hitting .291 with 12 doubles, a triple, nine home runs and 25 walks.

Diamondbacks Team Props

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FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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