Diamondbacks vs. Phillies Prediction, Odds, Picks - September 21

Geraldo Perdomo and the Arizona Diamondbacks will try to find success against Ranger Suarez when he starts for the Philadelphia Phillies on Sunday at 4:10 p.m. ET. The Phillies are listed as -106 moneyline underdogs for this matchup with the favored Diamondbacks (-113). Philadelphia is favored on the run line (-1.5 with +150 odds). A 9-run over/under has been set for this contest.

Here is everything you need to know from a betting perspective on the Diamondbacks-Phillies game, regarding the run line, moneyline and total, plus expert picks.

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Diamondbacks vs. Phillies Game Information & Odds

• When: Sunday, September 21, 2025 at 4:10 p.m. ET
• Where: Chase Field in Phoenix, Arizona
• How to watch on TV: ARID and NBCS-PH

Diamondbacks vs. Phillies Prediction

• Score Prediction: Diamondbacks 6, Phillies 5
• Total Prediction: Over 9 runs
• Win Probabilities: Diamondbacks 50%, Phillies 50%

Diamondbacks vs. Phillies Betting Insights

• This season, the Diamondbacks have been favored 89 times and won 46, or 51.7%, of those games.
• Arizona has entered 83 games this season favored by -113 or more and is 43-40 in those contests.
• The Diamondbacks have a 53.1% chance to win this game based on the implied probability of the moneyline.
• The Phillies have been underdogs in 33 games this season and have come away with the win 16 times (48.5%) in those contests.
• This year, Philadelphia has won 15 of 29 games when listed as at least -106 or worse on the moneyline.
• The Phillies have an implied victory probability of 51.5% according to the moneyline set by oddsmakers for this matchup.

Diamondbacks Recent Betting Performance

• The Diamondbacks have a 3-2 record over the five games they were a moneyline favorite in their last 10 matchups.
• Over their last 10 outings, the Diamondbacks and their opponents combined to go over the total five times (all 10 games had set totals).
• The Diamondbacks have a 6-4-0 record against the spread over their past 10 games.

Diamondbacks Recent Stats

Diamondbacks Player Insights

• Perdomo has racked up a team-high batting average of .289 while pacing the Diamondbacks in runs batted in (97).
• Perdomo's home runs rank him 85th in MLB, and he is 14th in RBI.
• Perdomo takes a hitting streak of 10 games into this game. During his last 10 games he is batting .412 with four doubles, a triple, two home runs, nine walks and six RBIs.
• Corbin Carroll's 30 home runs are a team-high mark.
• Carroll is 19th in homers in MLB, and 48th in RBI.
• Carroll enters this matchup looking for his seventh game in a row with a hit. In his last 10 games he is batting .270 with a double, a triple, nine walks and five RBIs.
• Ketel Marte has 25 doubles, 26 home runs and 63 walks while batting .279.
• Marte will look to build on his two-game hitting in this game. In his last five games he is batting .261 with two doubles, a home run and three RBIs.
• Gabriel Moreno has 12 doubles, a triple, nine home runs and 25 walks while hitting .285.
• Moreno brings a two-game streak with at least one hit into this one. During his last five outings he is batting .176 with a double and five walks.

Diamondbacks Team Props

Phillies Recent Betting Performance

• The Phillies have played as underdogs in five of their past 10 games and won three of those contests.
• The Phillies and their opponents have combined to hit the over eight times in their last 10 games with a total.
• The Phillies have a record of 6-4-0 ATS over their last 10 games.

Phillies Recent Stats

Phillies Player Insights

• Kyle Schwarber has put up a team-leading 53 home runs and has driven in 129 runs.
• Among all batters in the majors, Schwarber is second in homers and first in RBI.
• Bryce Harper is hitting .263 with 32 doubles, 27 home runs and 68 walks.
• Harper ranks 34th in homers and 62nd in RBI among all major league hitters this season.
• Bryson Stott is hitting .257 with 21 doubles, three triples, 12 home runs and 53 walks.
• Nick Castellanos is hitting .255 with 27 doubles, two triples, 17 home runs and 31 walks.

Phillies Team Props

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FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Arizona Diamondbacks

Philadelphia Phillies