Diamondbacks vs. Guardians Prediction, Odds, Picks - August 19

Ketel Marte and the Arizona Diamondbacks will square off against Jose Ramirez and the Cleveland Guardians at Chase Field on Tuesday. The favored Diamondbacks have -120 moneyline odds against the underdog Guardians, who are listed at +100. Cleveland is favored on the run line (-1.5 with +160 odds). The over/under for the matchup is set at 8.5 runs.

Here's everything you need from a betting perspective on the Diamondbacks-Guardians game, regarding the run line, moneyline and total, plus expert picks.

Keep up with MLB on FOX Sports.

Diamondbacks vs. Rockies Highlights | MLB on FOX

Check out the best moments between the Arizona Diamondbacks and Colorado Rockies.

Diamondbacks vs. Guardians Game Information & Odds

• When: Tuesday, August 19, 2025 at 9:40 p.m. ET
• Where: Chase Field in Phoenix, Arizona
• How to watch on TV: MLB Network, ARID, and CLEG

Diamondbacks vs. Guardians Prediction

• Score Prediction: Diamondbacks 6, Guardians 5
• Total Prediction: Over 8.5 runs
• Win Probabilities: Diamondbacks 52%, Guardians 48%

Diamondbacks vs. Guardians Betting Insights

• This season, the Diamondbacks have won 38 out of the 76 games, or 50%, in which they've been favored.
• Arizona is 28-31 this season when entering a game favored by -120 or more on the moneyline.
• Oddsmakers have implied with the moneyline set for this matchup that the Diamondbacks have a 54.5% chance to win.
• The Guardians have come away with 30 wins in the 66 contests they have been listed as the underdogs in this season.
• This season, Cleveland has been victorious 23 times in 52 chances when named as an underdog of at least +100 or worse on the moneyline.
• The moneyline set for this matchup implies the Guardians have a 50% chance of walking away with the win.

Diamondbacks Recent Betting Performance

• The Diamondbacks went 3-4 over the seven games they were favored on the moneyline in their last 10 matchups.
• In their last 10 matchups (all had set totals), the Diamondbacks combined with their opponents to go over the run total five times.
• The Diamondbacks' record against the spread is 5-5-0 over their past 10 games.

Diamondbacks Recent Stats

Diamondbacks Player Insights

• Geraldo Perdomo is the Diamondbacks RBI leader this season, knocking in 80 runs to go with his 13 home runs and .287 batting average.
• Perdomo's home runs rank him 115th in MLB, and he is 15th in RBI.
• Perdomo has collected a hit in three straight games. In his last five games he is hitting .300 with a triple, four walks and an RBI.
• Corbin Carroll's 27 home runs pace his team.
• Carroll is 11th in home runs in MLB, and 52nd in RBI.
• Carroll carries a six-game streak with at least one hit into this contest. During his last 10 games he is hitting .286 with two doubles, three home runs, six walks and six RBIs.
• Marte has a team-high batting average of .295.
• Lourdes Gurriel Jr. is batting .247 with 23 doubles, two triples, 16 home runs and 29 walks.
• Gurriel brings a five-game streak with at least one hit into this one. In his last five games he is batting .300 with a double, two home runs, a walk and seven RBIs.

Diamondbacks Team Props

Guardians Recent Betting Performance

• Over the past 10 games, the Guardians have been underdogs just once and won that contest.
• When it comes to hitting the over, the Guardians and their opponents are 5-4-1 in their last 10 games with a total.
• The Guardians have a record of 5-5-0 ATS over their last 10 games.

Guardians Recent Stats

Guardians Player Insights

• Ramirez leads the squad with a batting average of .290, and leads the Guardians in home runs, with 25 and runs batted in with 64.
• Ramirez's home run total places him 18th in the majors, and he ranks 52nd in RBI.
• Steven Kwan has 22 doubles, a triple, 10 home runs and 42 walks while hitting .280.
• Kwan is 159th among all batters in the big leagues in home runs, and 172nd in RBI.
• Carlos Santana has nine doubles, 11 home runs and 52 walks while batting .227.
• Kyle Manzardo has 14 doubles, two triples, 21 home runs and 40 walks while batting .236.

Guardians Team Props

Diamondbacks vs. Rockies Highlights | MLB on FOX

Check out the best moments between the Arizona Diamondbacks and Colorado Rockies.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

Want great stories delivered right to your inbox? Create or log in to your FOX Sports account, follow leagues, teams and players to receive a personalized newsletter daily.

FOLLOW Follow your favorites to personalize your FOX Sports experience

Arizona Diamondbacks

Cleveland Guardians