Cubs vs. White Sox Prediction, Odds, Picks - July 25

Kyle Tucker and Andrew Benintendi will be among the star attractions when the Chicago Cubs face the Chicago White Sox on Friday at 7:40 p.m. ET, at Rate Field. The Cubs are listed as -183 moneyline favorites in this matchup with the White Sox (+152). The Cubs are favored on the run line (-1.5). The matchup's total is set at 8 runs.

Check out everything you need from a betting perspective on the Cubs-White Sox game, regarding the run line, moneyline and total, plus expert picks.

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Guardians vs. White Sox Highlights | MLB on FOX

Check out the best moments between the Cleveland Guardians and the Chicago White Sox..

Cubs vs. White Sox Game Information & Odds

• When: Friday, July 25, 2025 at 7:40 p.m. ET
• Where: Rate Field in Chicago, Illinois
• How to watch on TV: CHSN and MARQ

Cubs vs. White Sox Prediction

• Score Prediction: Cubs 4, White Sox 3
• Total Prediction: Under 8 runs
• Win Probabilities: Cubs 54%, White Sox 46%

Cubs vs. White Sox Betting Insights

• The Cubs have won 48, or 68.6%, of the 70 games they've played as favorites this season.
• This season, the Cubs have won 13 of their 14 games, or 92.9%, when favored by at least -183 on the moneyline.
• The Cubs have a 64.7% chance to win this game based on the implied probability of the moneyline.
• The White Sox have been underdogs in 101 games this season and have come away with the win 36 times (35.6%) in those contests.
• This year, the White Sox have won 14 of 51 games when listed as at least +152 or better on the moneyline.
• Oddsmakers have implied with the moneyline set for this matchup that the White Sox have a 39.7% chance of pulling out a win.

Cubs Recent Betting Performance

• The Cubs were the moneyline favorite in six of their last 10 games, and they finished 4-2 in those matchups.
• In their last 10 matchups, the Cubs and their opponents combined to hit the over on the run total four times (all 10 games had set totals).
• The Cubs have gone 6-4-0 against the spread over their past 10 games.

Cubs Recent Stats

Cubs Player Insights

• Tucker has 19 doubles, four triples, 18 home runs and 65 walks while hitting .275.
• In all of Major League Baseball, Tucker ranks 34th in homers and 37th in RBI.
• Pete Crow-Armstrong's 27 home runs are a team-high mark.
• Among all major league hitters, Crow-Armstrong is sixth in home runs and ninth in RBI.
• Crow-Armstrong enters this game looking for his seventh game in a row with a hit. During his last 10 outings he is hitting .275 with five doubles, four home runs, a walk and seven RBIs.
• Seiya Suzuki paces the Cubs with 81 runs batted in.
• Nico Hoerner has a club-leading .286 batting average.
• Hoerner has recorded at least one hit in two games in a row. In his last five games he is hitting .350 with an RBI.

Cubs Team Props

White Sox Recent Betting Performance

• In 10 games over the last 10 matchups when set as underdogs by oddsmakers, the White Sox had a record of 6-4.
• When it comes to hitting the over, the White Sox and their opponents are 6-4-0 in their last 10 games with a total.
• The White Sox have a record of 8-2-0 ATS over their last 10 games.

White Sox Recent Stats

White Sox Player Insights

• Miguel Vargas has swatted a team-high 12 long balls.
• Vargas' home run total puts him 101st in MLB, and he is 117th in RBI.
• Benintendi is hitting .236 with 12 doubles, two triples, 11 home runs and 27 walks.
• Benintendi is 113th in homers and 142nd in RBI among all major league hitters this season.
• Luis Robert has driven in a team-high 41 runs batted in.
• Chase Meidroth is hitting .250 with 11 doubles, two home runs and 32 walks.

White Sox Team Props

Guardians vs. White Sox Highlights | MLB on FOX

Check out the best moments between the Cleveland Guardians and the Chicago White Sox..

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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