Cubs vs. Rays Prediction, Odds, Picks - September 12

The Chicago Cubs and Nico Hoerner ready for the first of a three-game series against Yandy Diaz and the Tampa Bay Rays on Friday at Wrigley Field. The Cubs are favored in this one, at -165, while the underdog Rays have +138 odds to play spoiler. Chicago is the run-line favorite (-1.5). The over/under is 7.5 runs for this contest (with +106 odds on the over and -126 odds on the under).

Here is everything you need from a betting perspective on the Cubs-Rays game, regarding the run line, moneyline and total, plus expert picks.

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Cubs vs. Rays Game Information & Odds

• When: Friday, September 12, 2025 at 2:20 p.m. ET
• Where: Wrigley Field in Chicago, Illinois
• How to watch on TV: MLB Network, MARQ, and FDSSUN

Cubs vs. Rays Prediction

• Score Prediction: Cubs 5, Rays 4
• Total Prediction: Over 7.5 runs
• Win Probabilities: Cubs 55%, Rays 45%

Cubs vs. Rays Betting Insights

• This season, the Cubs have been favored 106 times and won 66, or 62.3%, of those games.
• This season Chicago has won 27 of its 42 games, or 64.3%, when favored by at least -165 on the moneyline.
• The Cubs have a 62.3% chance to win this game based on the implied probability of the moneyline.
• The Rays have been chosen as underdogs in 70 games this year and have walked away with the win 29 times (41.4%) in those games.
• Tampa Bay has a win-loss record of 5-9 when favored by +138 or worse by oddsmakers this year.
• The moneyline set for this matchup implies the Rays have a 42% chance of coming away with a victory in the contest.

Cubs Recent Betting Performance

• The Cubs were favored on the moneyline for nine of their last 10 games, and they went 4-5 in those matchups.
• In their last 10 outings (all 10 of them had set totals), the Cubs and their opponents combined to hit the over three times.
• The Cubs are 3-7-0 against the spread over their past 10 games.

Cubs Recent Stats

Cubs Player Insights

• Pete Crow-Armstrong has left the yard 28 times this season, the highest mark on the Cubs, while hitting .251 with 87 RBI.
• Of all hitters in the majors, Crow-Armstrong's home run total places him 21st, and his RBI tally puts him 23rd.
• Nico Hoerner's .294 batting average leads his team.
• Hoerner ranks 269th in home runs and 119th in RBI on the year.
• Hoerner carries a six-game streak with at least one hit into this contest. During his last 10 outings he is hitting .317 with four doubles, a home run, three walks and three RBIs.
• Seiya Suzuki leads the Cubs with 91 runs batted in.
• Suzuki is on a six-game hitting streak entering this contest. In his last 10 outings he is batting .211 with a double, six walks and four RBIs.
• Ian Happ is batting .237 with 27 doubles, 20 home runs and 79 walks.
• Happ is riding a two-game hitting streak into this one. In his last five games he is batting .190 with a double and two walks.

Cubs Team Props

Rays Recent Betting Performance

• Over the past 10 games, the Rays have been underdogs twice and won both contests.
• In their last 10 games with a total, the Rays and their opponents are 6-4-0 when it comes to hitting the over.
• The Rays have four wins against the spread in their last 10 chances.

Rays Recent Stats

Rays Player Insights

• Junior Caminero has put up a team-leading 42 home runs and has driven in 106 runs.
• Caminero's home run total puts him sixth in MLB, and he is sixth in RBI.
• Yandy Diaz is batting .292 to lead the lineup.
• Among all MLB hitters, Diaz is 49th in home runs and 40th in RBI.
• Brandon Lowe is hitting .260 with 17 doubles, 28 home runs and 36 walks.
• Chandler Simpson has 11 doubles, three triples and 18 walks while hitting .292.

Rays Team Props

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FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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