Cubs vs. Nationals Prediction, Odds, Picks - September 5

Ian Happ and the Chicago Cubs will square off against C.J. Abrams and the Washington Nationals at Wrigley Field on Friday. The Cubs are favored in this one, at -215, while the underdog Nationals have +177 odds to upset. Chicago is the run-line favorite (-1.5). The total is 10.5 runs for this game (with -110 odds to hit the over and -110 odds on the under).

Take a look at everything you need to know from a betting perspective on the Cubs-Nationals game, regarding the run line, moneyline and total, plus expert picks.

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Marlins vs. Nationals Highlights | MLB on FOX

Check out the best moments between the Miami Marlins and the Washington Nationals.

Cubs vs. Nationals Game Information & Odds

• When: Friday, September 5, 2025 at 2:20 p.m. ET
• Where: Wrigley Field in Chicago, Illinois
• How to watch on TV: Apple TV+

Cubs vs. Nationals Prediction

• Score Prediction: Cubs 5, Nationals 3
• Total Prediction: Under 10.5 runs
• Win Probabilities: Cubs 61%, Nationals 39%

Cubs vs. Nationals Betting Insights

• The Cubs have won 64, or 63.4%, of the 101 games they've played as favorites this season.
• Chicago has entered 16 games this season favored by -215 or more and is 13-3 in those contests.
• The implied probability of a win from the Cubs, based on the moneyline, is 68.3%.
• The Nationals have been underdogs in 120 games this season and have come away with the win 50 times (41.7%) in those contests.
• This year, Washington has won five of 18 games when listed as at least +177 or worse on the moneyline.
• The moneyline set for this matchup implies the Nationals have a 36.1% chance of walking away with the win.

Cubs Recent Betting Performance

• The Cubs played as the moneyline favorite in nine of their last 10 games, and they finished 5-4 in those matchups.
• In their last 10 matchups, the Cubs and their opponents combined to go over the run total three times (all 10 games had set totals).
• The Cubs are 1-9-0 against the spread over their past 10 games.

Cubs Recent Stats

Cubs Player Insights

• Kyle Tucker has 25 doubles, four triples, 22 home runs and 86 walks while hitting .270.
• Among all batters in the majors, Tucker's home run total places him 48th, and his RBI tally puts him 47th.
• Pete Crow-Armstrong has hit 28 home runs to pace his team.
• Crow-Armstrong ranks 18th in home runs and 21st in RBI in the major leagues.
• Nico Hoerner paces the Cubs with a .288 batting average.
• Seiya Suzuki has collected 89 runs batted in to lead his team.

Cubs Team Props

Nationals Recent Betting Performance

• In eight games over the last 10 matchups when set as underdogs by oddsmakers, the Nationals had a record of 1-7.
• The Nationals and their opponents have combined to hit the over four times in their last 10 games with a total.
• The Nationals have won four of their last 10 games against the spread.

Nationals Recent Stats

Nationals Player Insights

• Abrams leads the team in batting average with a high-water mark of .265.
• In all of the majors, Abrams ranks 92nd in homers and 128th in RBI.
• James Wood has been a reliable source of runs this year, leading the lineup with 27 home runs and 86 RBI.
• Wood is 24th overall in home runs and 20th in RBI this season.
• Luis Garcia has 26 doubles, a triple, 11 home runs and 23 walks while hitting .260.
• Josh Bell is hitting .224 with 12 doubles, a triple, 16 home runs and 53 walks.

Nationals Team Props

Marlins vs. Nationals Highlights | MLB on FOX

Check out the best moments between the Miami Marlins and the Washington Nationals.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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