Cubs vs. Mariners Prediction, Odds, Picks - June 21

Julio Rodriguez and the Seattle Mariners will hit the field on Saturday at Wrigley Field against Cade Horton, who is expected to start for the Chicago Cubs. First pitch is set for 2:20 p.m. ET for the second game of a three-game series. Oddsmakers list the Cubs as -169 moneyline favorites, while giving the underdog Mariners +142 moneyline odds to win. Chicago (-1.5) is favored on the run line. The contest's total has been set at 12.5 runs.

Here is everything you need to know from a betting perspective on the Cubs-Mariners game, regarding the run line, moneyline and total, plus expert picks.

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Cubs vs. Mariners Game Information & Odds

• When: Saturday, June 21, 2025 at 2:20 p.m. ET
• Where: Wrigley Field in Chicago, Illinois
• How to watch on TV: MARQ and ROOT Sports NW

Cubs vs. Mariners Prediction

• Score Prediction: Cubs 4, Mariners 3
• Total Prediction: Under 12.5 runs
• Win Probabilities: Cubs 58%, Mariners 42%

Cubs vs. Mariners Betting Insights

• This season, the Cubs have won 36 out of the 52 games, or 69.2%, in which they've been favored.
• Chicago is 12-4 this season when entering a game favored by -169 or more on the moneyline.
• The implied probability of a win from the Cubs, based on the moneyline, is 62.8%.
• The Mariners have been victorious in 13, or 50%, of the 26 contests they have been chosen as underdogs in this season.
• This season, Seattle has been victorious three times in four chances when named as an underdog of at least +142 or worse on the moneyline.
• Sportsbooks have implied with the moneyline set for this matchup that the Mariners have a 41.3% chance of pulling out a win.

Cubs Recent Betting Performance

• The Cubs were the moneyline favorite for eight of their last 10 games, and finished 5-3 in those matchups.
• In their last 10 outings -- all had a set run total -- the Cubs and their opponents combined to hit the over on the total three times.
• The Cubs have put together a 4-6-0 record against the spread over their past 10 games.

Cubs Recent Stats

Cubs Player Insights

• Kyle Tucker has 16 doubles, four triples, 13 home runs and 50 walks while batting .284.
• Tucker ranks 32nd in homers and 36th in RBI among all hitters in the majors.
• Pete Crow-Armstrong has hit 20 home runs to lead his team.
• Crow-Armstrong is sixth in home runs and sixth in RBI in the bigs.
• Seiya Suzuki has put up a team-high 61 runs batted in.
• Nico Hoerner is batting .287 to lead his team.
• Hoerner has recorded at least one hit in six games in a row. During his last 10 outings he is batting .297 with two doubles, a walk and two RBIs.

Cubs Team Props

Mariners Recent Betting Performance

• In five games over the last 10 matchups when set as underdogs by oddsmakers, the Mariners had a record of 1-4.
• In their last 10 games with a total, the Mariners and their opponents have combined to hit the over five times.
• The Mariners have a record of 4-6-0 ATS over their last 10 games.

Mariners Recent Stats

Mariners Player Insights

• Cal Raleigh has managed a team-leading 29 home runs and has driven in 63 runs.
• Among all batters in the big leagues, Raleigh's home run total is first and his RBI tally ranks third.
• Raleigh brings a hitting streak of three games into this game. During his last five outings he is hitting .400 with two doubles, three home runs, a walk and nine RBIs.
• Rodriguez has nine doubles, three triples, 10 home runs and 21 walks while hitting .253.
• Rodriguez is 65th among all hitters in MLB in home runs, and 84th in RBI.
• J.P. Crawford has accumulated a team-high batting average of .288.
• Jorge Polanco has eight doubles, 11 home runs and 13 walks while hitting .254.

Mariners Team Props

Brewers vs. Cubs Highlights | MLB on FOX

Check out the best moments between the Milwaukee Brewers and the Chicago Cubs.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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