Cardinals vs. Pirates Prediction, Odds, Picks - August 27

Nolan Gorman and the St. Louis Cardinals will try to out-hit Spencer Horwitz and the Pittsburgh Pirates at Busch Stadium on Wednesday at 7:45 p.m. ET. The Pirates have been listed as +145 moneyline underdogs in this matchup against the favored Cardinals (-175). St. Louis is favored on the run line (-1.5 with +124 odds). The total is 7.5 runs for the matchup.

Check out everything you need from a betting perspective on the Cardinals-Pirates game, regarding the run line, moneyline and total, plus expert picks.

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Pirates vs. Cardinals Highlights | MLB on FOX

Check out the best moments between the Pittsburgh Pirates and the St. Louis Cardinals.

Cardinals vs. Pirates Game Information & Odds

• When: Wednesday, August 27, 2025 at 7:45 p.m. ET
• Where: Busch Stadium in St. Louis, Missouri
• How to watch on TV: Fox Sports 1, FDSMW, and SportsNet PT

Cardinals vs. Pirates Prediction

• Score Prediction: Cardinals 5, Pirates 4
• Total Prediction: Over 7.5 runs
• Win Probabilities: Cardinals 53%, Pirates 47%

Cardinals vs. Pirates Betting Insights

• The Cardinals have been favorites in 60 games this season and won 31 (51.7%) of those contests.
• This season St. Louis has won five of its eight games when favored by at least -175 on the moneyline.
• The sportsbooks' moneyline implies a 63.6% chance of a victory for the Cardinals.
• The Pirates have come away with 37 wins in the 91 contests they have been listed as the underdogs in this season.
• Pittsburgh has a mark of 9-22 in contests where oddsmakers favor it by +145 or worse on the moneyline.
• Bookmakers have implied with the moneyline set for this matchup that the Pirates have a 40.8% chance of pulling out a win.

Cardinals Recent Betting Performance

• The Cardinals were the moneyline favorite in three of their last 10 games, and they finished 2-1 in those matchups.
• Over their last 10 outings, the Cardinals and their opponents combined to go over the total eight times (all 10 games had set totals).
• The Cardinals' record against the spread is 3-7-0 over their past 10 games.

Cardinals Recent Stats

Cardinals Player Insights

• Alec Burleson has a team-high batting average of .291.
• Among all batters in MLB, Burleson is 92nd in home runs and 77th in RBI.
• Burleson takes a hitting streak of four games into this matchup. In his last five games he is batting .364 with a double, a home run and three RBIs.
• Willson Contreras' 19 home runs and 73 runs batted in both lead his team.
• Contreras ranks 62nd in homers and 36th in RBI among all batters in MLB.
• Masyn Winn has 26 doubles, nine home runs and 31 walks while hitting .256.
• Lars Nootbaar is hitting .234 with 20 doubles, 13 home runs and 52 walks.

Cardinals Team Props

Pirates Recent Betting Performance

• The Pirates have played as underdogs in six of their past 10 games and have gone 2-4 in those contests.
• In their last 10 games with a total, the Pirates and their opponents have failed to hit the over six times.
• The Pirates have a record of 8-2-0 ATS over their last 10 games.

Pirates Recent Stats

Pirates Player Insights

• Bryan Reynolds has driven in the most runs for the Pirates with 66 runs batted in.
• Reynolds ranks 117th in home runs and 57th in RBI among all hitters in MLB.
• Oneil Cruz has hit a team-high 18 home runs.
• Cruz ranks 70th in home runs and 116th in RBI among all hitters in the big leagues.
• Andrew McCutchen is hitting .241 with 19 doubles, 12 home runs and 54 walks.
• Isiah Kiner-Falefa paces the Pirates with a .267 batting average.

Pirates Team Props

Pirates vs. Cardinals Highlights | MLB on FOX

Check out the best moments between the Pittsburgh Pirates and the St. Louis Cardinals.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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