Cardinals vs. Guardians Prediction, Odds, Picks - June 27

Sonny Gray and the St. Louis Cardinals will hit the field against the Cleveland Guardians and starting pitcher Luis Ortiz on Friday at Progressive Field. The favored Cardinals have -130 moneyline odds against the underdog Guardians, who are listed at +109. St. Louis is favored on the run line (-1.5 with +130 odds). An 8.5-run over/under is set in the game.

Here's everything you need from a betting perspective on the Cardinals-Guardians game, regarding the run line, moneyline and total, plus expert picks.

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Blue Jays vs. Guardians Highlights | MLB on FOX

Check out the best moments between the Toronto Blue Jays and the Cleveland Guardians.

Cardinals vs. Guardians Game Information & Odds

• When: Friday, June 27, 2025 at 7:10 p.m. ET
• Where: Progressive Field in Cleveland, Ohio
• How to watch on TV: Apple TV+

Cardinals vs. Guardians Prediction

• Score Prediction: Cardinals 5, Guardians 4
• Total Prediction: Over 8.5 runs
• Win Probabilities: Cardinals 50%, Guardians 50%

Cardinals vs. Guardians Betting Insights

• The Cardinals have won 20, or 55.6%, of the 36 games they've played as favorites this season.
• This season St. Louis has won 12 of its 17 games, or 70.6%, when favored by at least -130 on the moneyline.
• Oddsmakers have implied with the moneyline set for this matchup that the Cardinals have a 56.5% chance to win.
• The Guardians have come away with 21 wins in the 47 contests they have been listed as the underdogs in this season.
• This season, Cleveland has been victorious 10 times in 29 chances when named as an underdog of at least +109 or worse on the moneyline.
• The Guardians have an implied victory probability of 47.8% according to the moneyline set for this matchup.

Cardinals Recent Betting Performance

• The Cardinals played five of their last 10 games as a moneyline favorite, and won all of them.
• In their last 10 matchups, the Cardinals and their opponents combined to go over the total five times (all 10 games had set totals).
• The Cardinals' ATS record is 5-5-0 over their past 10 games.

Cardinals Recent Stats

Cardinals Player Insights

• Nolan Arenado is batting .242 with 11 doubles, a triple, 10 home runs and 24 walks.
• Arenado is 84th in homers and 68th in RBI among all hitters in MLB.
• Brendan Donovan has a club-leading .301 batting average.
• Donovan is 203rd in home runs and 134th in RBI among all major league hitters this year.
• Lars Nootbaar has launched a team-high 11 home runs.
• Nootbaar is on a six-game hitting streak entering this contest. During his last 10 games he is hitting .184 with a double, three home runs, six walks and seven RBIs.
• Willson Contreras has totaled 50 runs batted in to lead his team.

Cardinals Team Props

Guardians Recent Betting Performance

• The Guardians have played as underdogs in five of their past 10 games and have gone 2-3 in those contests.
• When it comes to hitting the over, the Guardians and their opponents are 2-8-0 in their last 10 games with a total.
• The Guardians have a record of 5-5-0 ATS over their last 10 games.

Guardians Recent Stats

Guardians Player Insights

• Jose Ramirez leads the Guardians with 13 home runs and 38 runs batted in, while recording a team-high batting average of .317.
• In all of the majors, Ramirez is 39th in homers and 73rd in RBI.
• Steven Kwan is batting .306 with 18 doubles, six home runs and 28 walks.
• Kwan is 169th in homers and 181st in RBI among all hitters in the majors.
• Carlos Santana is batting .234 with six doubles, nine home runs and 35 walks.
• Kyle Manzardo is hitting .222 with 11 doubles, two triples, 12 home runs and 25 walks.

Guardians Team Props

Blue Jays vs. Guardians Highlights | MLB on FOX

Check out the best moments between the Toronto Blue Jays and the Cleveland Guardians.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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