Brewers vs. Orioles Prediction, Odds, Picks - May 21

Ryan O'Hearn and the Baltimore Orioles will take the field on Wednesday at American Family Field against Chad Patrick, who is projected to start for the Milwaukee Brewers. First pitch will be at 1:10 p.m. ET. The Brewers are the favorite in this one, at -116, while the underdog Orioles have -104 odds to win. Baltimore is the run-line favorite (-1.5). The over/under is 8 runs for the matchup (with -117 odds to go over and -103 odds to go under).

Check out everything you need from a betting perspective on the Brewers-Orioles game, regarding the run line, moneyline and total, plus expert picks.

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Orioles vs. Brewers Highlights | MLB on FOX

Check out the best moments between the Baltimore Orioles and the Milwaukee Brewers.

Brewers vs. Orioles Game Information & Odds

• When: Wednesday, May 21, 2025 at 1:10 p.m. ET
• Where: American Family Field in Milwaukee, Wisconsin
• How to watch on TV: MLB Network, FDSWI, and MASN2

Brewers vs. Orioles Prediction

• Score Prediction: Brewers 5, Orioles 3
• Total Prediction: Under 8 runs
• Win Probabilities: Brewers 59%, Orioles 41%

Brewers vs. Orioles Betting Insights

• This season, the Brewers have won 17 out of the 24 games, or 70.8%, in which they've been favored.
• Milwaukee has entered 23 games this season favored by -116 or more and is 16-7 in those contests.
• The moneyline for this contest implies a 53.7% chance of a victory for the Brewers.
• The Orioles have been chosen as underdogs in 19 games this year and have walked away with the win six times (31.6%) in those games.
• This year, Baltimore has won five of 17 games when listed as at least -104 or worse on the moneyline.
• The Orioles have an implied victory probability of 51% according to the moneyline set for this matchup.

Brewers Recent Betting Performance

• The Brewers were the moneyline favorite for four of their last 10 games, and they finished 3-1 in those matchups.
• Over their last 10 outings (all 10 of them had set totals), the Brewers and their opponents combined to hit the over two times.
• The Brewers have gone 6-4-0 against the spread over their past 10 games.

Brewers Recent Stats

Brewers Player Insights

• Brice Turang leads the Brewers with a .297 batting average.
• Of all batters in the majors, Turang's home run total ranks him 145th, and his RBI tally ranks him 113th.
• Turang takes a hitting streak of two games into this game. During his last five outings he is batting .350 with a double, a home run, two walks and three RBIs.
• William Contreras is batting .255 with six doubles, four home runs and 31 walks.
• Contreras is 145th in homers and 74th in RBI among all hitters in baseball.
• Sal Frelick is batting .282 with five doubles, three triples, three home runs and 16 walks.
• Frelick will look to build on his three-game hitting in this matchup. In his last five games he is batting .375 with a triple, a home run, two walks and four RBIs.
• Jackson Chourio's seven home runs are a team-high mark.

Brewers Team Props

Orioles Recent Betting Performance

• Over the past 10 games, the Orioles have been underdogs twice and lost both contests.
• In their last 10 games with a total, the Orioles and their opponents have combined to hit the over six times.
• The Orioles have a record of 1-9-0 ATS over their last 10 games.

Orioles Recent Stats

Orioles Player Insights

• Cedric Mullins paces the Orioles in home runs (10) and runs batted in (30).
• Mullins' home run total places him 19th in the big leagues, and he is 22nd in RBI.
• Mullins carries a three-game hitting streak into this matchup. During his last five outings he is hitting .211 with a double, two home runs, two walks and five RBIs.
• O'Hearn is batting .289 to lead the lineup.
• O'Hearn is 63rd in home runs and 182nd in RBI among all hitters in MLB.
• Jackson Holliday has four doubles, two triples, six home runs and 10 walks while hitting .272.
• Gunnar Henderson has eight doubles, two triples, seven home runs and 11 walks while hitting .253.

Orioles Team Props

Orioles vs. Brewers Highlights | MLB on FOX

Check out the best moments between the Baltimore Orioles and the Milwaukee Brewers.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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