Brewers vs. Giants Prediction, Odds, Picks - August 22

Christian Yelich and the Milwaukee Brewers will square off against Rafael Devers and the San Francisco Giants at American Family Field in the first of a three-game series, Friday at 8:10 p.m. ET. The Brewers are the favorite in this one, at -187, while the underdog Giants have +155 odds to upset. Milwaukee is the run-line favorite (-1.5). The contest's over/under is set at 9 runs.

Here's everything you need from a betting perspective on the Brewers-Giants game, regarding the run line, moneyline and total, plus expert picks.

Keep up with MLB on FOX Sports.

Giants vs. Padres Highlights | MLB on FOX

Check out the best moments from the matchup between the San Francisco Giants and the San Diego Padres

Brewers vs. Giants Game Information & Odds

• When: Friday, August 22, 2025 at 8:10 p.m. ET
• Where: American Family Field in Milwaukee, Wisconsin
• How to watch on TV: FDSWI and NBCS-BA

Brewers vs. Giants Prediction

• Score Prediction: Brewers 5, Giants 3
• Total Prediction: Under 9 runs
• Win Probabilities: Brewers 60%, Giants 40%

Brewers vs. Giants Betting Insights

• The Brewers have entered the game as favorites 68 times this season and won 47, or 69.1%, of those games.
• Milwaukee is 10-2 this season when entering a game favored by -187 or more on the moneyline.
• The Brewers have a 65.2% chance to win this game based on the implied probability of the moneyline.
• The Giants have won in 23, or 45.1%, of the 51 contests they have been named as odds-on underdogs this year.
• This season, San Francisco has been victorious one time in five chances when named as an underdog of at least +155 or worse on the moneyline.
• The Giants have an implied victory probability of 39.2% according to the moneyline set by oddsmakers for this matchup.

Brewers Recent Betting Performance

• The Brewers have a 4-2 record over the six games they were favored on the moneyline in their last 10 matchups.
• In their last 10 outings (all had set totals), the Brewers combined with their opponents to hit the over on the run total six times.
• The Brewers' ATS record is 6-4-0 over their past 10 games.

Brewers Recent Stats

Brewers Player Insights

• Yelich leads the Brewers in home runs (26) and runs batted in (87).
• Including all MLB batters, Yelich ranks 62nd in batting average, 50th in on-base percentage, and 54th in slugging.
• Brice Turang is hitting .286 with 24 doubles, 14 home runs and 47 walks.
• Turang is 112th in home runs and 54th in RBI in the major leagues.
• Turang carries a five-game streak with at least one hit into this contest. In his last five games he is hitting .450 with a double, two home runs, a walk and six RBIs.
• William Contreras has 22 doubles, 13 home runs and 71 walks while hitting .256.
• Sal Frelick's .300 batting average paces his team.
• Frelick is riding a five-game hitting streak into this one. In his last five games he is hitting .421 with two doubles, four walks and two RBIs.

Brewers Team Props

Giants Recent Betting Performance

• In six games over the last 10 matchups when set as underdogs by sportsbooks, the Giants had a record of 1-5.
• When it comes to hitting the over, the Giants and their opponents are 5-5-0 in their last 10 games with a total.
• The Giants have a record of 3-7-0 ATS over their last 10 games.

Giants Recent Stats

Giants Player Insights

• Devers leads the Giants in home runs (25) and runs batted in (83).
• Among all hitters in MLB, Devers is 22nd in homers and 12th in RBI.
• Jung Hoo Lee is batting .262 with 29 doubles, 10 triples, seven home runs and 40 walks.
• Lee is 231st in homers and 134th in RBI among all MLB hitters this season.
• Willy Adames is hitting .222 with 18 doubles, two triples, 20 home runs and 60 walks.
• Heliot Ramos leads the Giants with a team-high batting average of .263.

Giants Team Props

Chris 'The Bear' Fallica on favorite bets, NFL awards odds, Brewers success | FULL INTERVIEW | The Herd

Chris “the Bear” Fallica joins Danny Parkins to discuss the Brewers World Series chances, favorite college football bets, Dark horse NFL MVP candidates, Travis Hunter’s chances to win rookie of the year, and how much the NFL preseason impacts the betting market.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

Want great stories delivered right to your inbox? Create or log in to your FOX Sports account, follow leagues, teams and players to receive a personalized newsletter daily.

FOLLOW Follow your favorites to personalize your FOX Sports experience

Milwaukee Brewers

San Francisco Giants