Brewers vs. Cubs Prediction, Odds, Picks - May 4

Published May. 3, 2025 9:00 p.m. ET

Data Skrive

The Milwaukee Brewers and Chicago Cubs will meet on Sunday at American Family Field, at 2:10 p.m. ET, with Jackson Chourio and Kyle Tucker -- two hot hitters -- expected to produce at the plate. The favored Brewers have -110 moneyline odds against the underdog Cubs, who are listed at -109. Chicago is the run-line favorite (-1.5). The over/under is 7.5 runs for this contest (with -111 odds to hit the over and -109 odds to go under).

Here is everything you need to know from a betting perspective on the Brewers-Cubs game, regarding the run line, moneyline and total, plus expert picks.

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Brewers vs. Cubs Game Information & Odds

When: Sunday, May 4, 2025 at 2:10 p.m. ET
Where: American Family Field in Milwaukee, Wisconsin
How to watch on TV: FDSWI and MARQ

Favorite	Favorite Moneyline	Underdog Moneyline	Total	Over Total Odds	Under Total Odds	Run Line	Favorite Run Line Odds	Underdog Run Line Odds
Brewers	-110	-109	7.5	-111	-109	-1.5	-188	+156

Brewers vs. Cubs Prediction

Score Prediction: Cubs 5, Brewers 4
Total Prediction: Over 7.5 runs
Win Probabilities: Brewers 53%, Cubs 47%

Brewers vs. Cubs Betting Insights

This season, the Brewers have been favored 17 times and won 12, or 70.6%, of those games.
Milwaukee has a record of 12-5 in games when oddsmakers favor them by at least -110 on the moneyline.
The moneyline for this contest implies a 52.4% chance of a victory for the Brewers.
The Cubs have been victorious in eight, or 50%, of the 16 contests they have been chosen as underdogs in this season.
Chicago has a win-loss record of 8-8 when favored by -109 or worse by sportsbooks this year.
The moneyline set for this matchup implies the Cubs have a 52.2% chance of coming away with a victory in the contest.

Brewers Recent Betting Performance

The Brewers have a 2-1 record across the three games they were favored on the moneyline in their last 10 matchups.
Over their last 10 matchups (all had set totals), the Brewers combined with their opponents to hit the over on the run total six times.
The Brewers have put together a 7-3-0 record against the spread over their past 10 games.

Brewers Recent Stats

Stat	Avg/Total
Record	4-6
Runs Per Game	4.5
HR	4
ERA	4.86
K/9	6.7

Brewers Player Insights

Chourio has gone yard six times in the 2025 campaign while driving in 24 runs, both totals that lead the Brewers.
Among all hitters in the majors, Chourio's home run total places him 35th, and his RBI tally puts him 14th.
Brice Turang has a club-best .315 batting average.
Of all major league hitters, Turang is 122nd in homers and 75th in RBI.
William Contreras is batting .252 with two doubles, three home runs and 20 walks.
Sal Frelick is hitting .307 with five doubles, two triples, a home run and 13 walks.

Cubs Recent Betting Performance

In three games as underdogs over the last 10 matchups, the Cubs have a record of 2-1.
In their last 10 games with a total, the Cubs and their opponents have failed to hit the over four times.
The Cubs have a record of 5-5-0 ATS over their last 10 games.

Cubs Recent Stats

Stat	Avg/Total
Record	6-4
Runs Per Game	5.9
HR	15
ERA	2.81
K/9	7.6

Cubs Player Insights

Tucker has recorded a team-high 29 runs batted in.
Among all hitters in MLB, Tucker's home run total is 15th and his RBI tally ranks fourth.
Pete Crow-Armstrong has 10 doubles, a triple, eight home runs and six walks while hitting .271.
Crow-Armstrong ranks 15th overall in homers and 18th in RBI this season.
Seiya Suzuki leads the Cubs in long balls (nine), runs batted in (29) and has a team-best batting average of .291.
Ian Happ is hitting .283 with nine doubles, two home runs and 21 walks.