Blue Jays vs. Astros Prediction, Odds, Picks - September 11

Vladimir Guerrero Jr. and the Toronto Blue Jays face Jose Altuve and the Houston Astros at Rogers Centre on Thursday. First pitch is at 3:07 p.m. ET. The Astros are +139 moneyline underdogs in this matchup against the favored Blue Jays (-165). Toronto is the run-line favorite (-1.5). An 8.5-run over/under has been set in this contest.

Check out everything you need from a betting perspective on the Blue Jays-Astros game, regarding the run line, moneyline and total, plus expert picks.

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Blue Jays vs. Astros Game Information & Odds

• When: Thursday, September 11, 2025 at 3:07 p.m. ET
• Where: Rogers Centre in Toronto, Ontario
• How to watch on TV: MLB Network, SNET, and SCHN

Blue Jays vs. Astros Prediction

• Score Prediction: Blue Jays 5, Astros 4
• Total Prediction: Over 8.5 runs
• Win Probabilities: Blue Jays 55%, Astros 45%

Blue Jays vs. Astros Betting Insights

• This season, the Blue Jays have been favored 71 times and won 41, or 57.7%, of those games.
• Toronto has entered 21 games this season favored by -165 or more and is 16-5 in those contests.
• The moneyline for this contest implies a 62.3% chance of a victory for the Blue Jays.
• The Astros have been chosen as underdogs in 51 games this year and have walked away with the win 29 times (56.9%) in those games.
• Houston has been a +139 moneyline underdog on four occasions this season and won every game.
• The moneyline set for this matchup implies the Astros have a 41.8% chance of walking away with the win.

Blue Jays Recent Betting Performance

• The Blue Jays were the moneyline favorite for five of their last 10 games, and finished 3-2 in those matchups.
• In their last 10 matchups -- all had a set run total -- the Blue Jays and their opponents combined to go over the total four times.
• The Blue Jays have put together a 6-4-0 record against the spread over their past 10 games.

Blue Jays Recent Stats

Blue Jays Player Insights

• Guerrero is batting .302 with 33 doubles, 23 home runs and 76 walks.
• Including all MLB batters, Guerrero ranks fifth in batting average, third in on-base percentage, and 21st in slugging.
• George Springer's 28 home runs are a team-high mark.
• Of all MLB hitters, Springer is 21st in homers and 54th in RBI.
• Ernie Clement is hitting .278 with 29 doubles, two triples, nine home runs and 24 walks.
• Clement will look to build on his five-game hitting in this game. In his last five games he is hitting .412 with four doubles, two walks and an RBI.
• Alejandro Kirk is batting .289 with 17 doubles, 12 home runs and 45 walks.

Blue Jays Team Props

Astros Recent Betting Performance

• The Astros have played as underdogs in seven of their past 10 games and won three of those contests.
• When it comes to hitting the over, the Astros and their opponents are 4-5-1 in their last 10 games with a total.
• The Astros have five wins against the spread in their last 10 chances.

Astros Recent Stats

Astros Player Insights

• Altuve has swatted a team-high 24 long balls.
• Among all hitters in the big leagues, Altuve's home run total is 42nd and his RBI tally is 69th.
• Jeremy Pena has a club-leading .299 batting average.
• Among all MLB batters, Pena ranks 126th in home runs and 126th in RBI.
• Yainer Diaz is hitting .256 with 22 doubles, a triple, 19 home runs and 20 walks.
• Carlos Correa is hitting .276 with 24 doubles, 13 home runs and 38 walks.

Astros Team Props

Blue Jays vs. Yankees Highlights | MLB on FOX

Check out the best highlights between the Toronto Blue Jays and the New York Yankees.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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