Astros vs. Guardians Prediction, Odds, Picks - July 7

The Houston Astros and Jose Altuve head into the first of a three-game series against Steven Kwan and the Cleveland Guardians on Monday at Daikin Park. The Guardians are +110 moneyline underdogs in this matchup against the favored Astros (-131). Houston (-1.5) is favored on the run line. A 7.5-run over/under has been set in the matchup.

Check out everything you need from a betting perspective on the Astros-Guardians game, regarding the run line, moneyline and total, plus expert picks.

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Astros vs. Guardians Game Information & Odds

• When: Monday, July 7, 2025 at 8:10 p.m. ET
• Where: Daikin Park in Houston, Texas
• How to watch on TV: SCHN and CLEG

Astros vs. Guardians Prediction

• Score Prediction: Astros 5, Guardians 4
• Total Prediction: Over 7.5 runs
• Win Probabilities: Astros 58%, Guardians 42%

Astros vs. Guardians Betting Insights

• The Astros have been favorites in 62 games this season and won 38 (61.3%) of those contests.
• Houston has entered 37 games this season favored by -131 or more and is 26-11 in those contests.
• The sportsbooks' moneyline implies a 56.7% chance of a victory for the Astros.
• The Guardians have been underdogs in 55 games this season and have come away with the win 21 times (38.2%) in those contests.
• This season, Cleveland has been victorious nine times in 32 chances when named as an underdog of at least +110 or worse on the moneyline.
• The Guardians have an implied victory probability of 47.6% according to the moneyline set by oddsmakers for this matchup.

Astros Recent Betting Performance

• The Astros went 5-2 over the seven games they were a moneyline favorite in their last 10 matchups.
• In their last 10 matchups (all 10 of them had set totals), the Astros and their opponents combined to go over the run total five times.
• The Astros have gone 6-4-0 against the spread over their past 10 games.

Astros Recent Stats

Astros Player Insights

• Isaac Paredes has a team-best 18 home runs and 48 runs batted in.
• Of all hitters in baseball, Paredes ranks 20th in home runs and 49th in RBI.
• Paredes has collected a hit in five games in a row. In his last five games he is batting .333 with two doubles, a home run, a walk and two RBIs.
• Jose Altuve is batting .272 with 12 doubles, a triple, 16 home runs and 31 walks.
• Altuve ranks 33rd in home runs and 57th in RBI among all batters in the majors.
• Altuve heads into this game looking for his sixth game in a row with a hit. In his last five games he is batting .500 with two doubles, a triple, three home runs, three walks and 10 RBIs.
• Jake Meyers is batting .308 with 15 doubles, two triples, three home runs and 27 walks.
• Yainer Diaz has 11 doubles, a triple, 12 home runs and 12 walks while hitting .248.
• Diaz is riding a five-game hitting streak into this one. In his last five games he is hitting .412 with two doubles, two home runs, two walks and three RBIs.

Astros Team Props

Guardians Recent Betting Performance

• The Guardians have played as underdogs eight times over their past 10 games and lost each of those contests.
• In their last 10 games with a total, the Guardians and their opponents have combined to hit the over three times.
• The Guardians have four wins against the spread in their last 10 chances.

Guardians Recent Stats

Guardians Player Insights

• Jose Ramirez leads the Guardians in home runs (14) and runs batted in (39).
• Ramirez is 45th in homers and 88th in RBI among all hitters in MLB.
• Steven Kwan is hitting .298 to lead the lineup.
• Kwan ranks 189th in home runs and 173rd in RBI among all batters in the majors.
• Carlos Santana is hitting .235 with seven doubles, 10 home runs and 39 walks.
• Kyle Manzardo has 11 doubles, two triples, 13 home runs and 25 walks while batting .217.

Guardians Team Props

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Check out the best moments between Houston Astros and Los Angeles Dodgers.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Houston Astros

Cleveland Guardians