Angels vs. Rockies Prediction, Odds, Picks - September 21

Caden Dana gets the nod for the Los Angeles Angels on Sunday against Mickey Moniak and the Colorado Rockies. First pitch is at 3:10 p.m. ET for this final game in a three-game series. The favored Angels have -126 moneyline odds against the underdog Rockies, who are listed at +106. Los Angeles (-1.5) is favored on the run line. An 11.5-run total is set in the contest.

Here is everything you need to know from a betting perspective on the Angels-Rockies game, regarding the run line, moneyline and total, plus expert picks.

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Angels vs. Rockies Highlights | MLB on FOX

Check out the best highlights between the Los Angeles Angels and the Colorado Rockies.

Angels vs. Rockies Game Information & Odds

• When: Sunday, September 21, 2025 at 3:10 p.m. ET
• Where: Coors Field in Denver, Colorado
• How to watch on TV: COLR and FDSW

Angels vs. Rockies Prediction

• Score Prediction: Angels 6, Rockies 5
• Total Prediction: Under 11.5 runs
• Win Probabilities: Angels 53%, Rockies 47%

Angels vs. Rockies Betting Insights

• The Angels have won 19, or 48.7%, of the 39 games they've played as favorites this season.
• Los Angeles is 11-13 this season when entering a game favored by -126 or more on the moneyline.
• The bookmakers' moneyline implies a 55.8% chance of a victory for the Angels.
• The Rockies have been victorious in 41, or 27.2%, of the 151 contests they have been chosen as underdogs in this season.
• Colorado has a mark of 38-107 in contests where sportsbooks favor it by +106 or worse on the moneyline.
• The Rockies have an implied victory probability of 48.5% according to the moneyline set by sportsbooks for this matchup.

Angels Recent Betting Performance

• The Angels have a 2-1 record from the three games they were favored on the moneyline over their last 10 matchups.
• Over their last 10 matchups (all 10 of them had set totals), the Angels and their opponents combined to hit the over six times.
• The Angels' ATS record is 3-7-0 over their past 10 games.

Angels Recent Stats

Angels Player Insights

• Taylor Ward leads the Angels with 101 runs batted in.
• Of all batters in the majors, Ward is 10th in home runs and 11th in RBI.
• Ward has collected a hit in four straight games. During his last five outings he is batting .368 with three home runs and three RBIs.
• Jo Adell's 36 home runs pace his team.
• Adell is ninth in home runs and 16th in RBI among all hitters in baseball.
• Nolan Schanuel has accumulated a team-high batting average of .268.
• Schanuel will look to build on his two-game hitting in this game. In his last five games he is batting .167 with a double, a home run and three RBIs.
• Mike Trout has 13 doubles, a triple, 22 home runs and 85 walks while batting .229.

Angels Team Props

Rockies Recent Betting Performance

• In 10 games over the last 10 matchups when set as underdogs by oddsmakers, the Rockies had a record of 2-8.
• In their last 10 games with a total, the Rockies and their opponents have combined to hit the over seven times.
• The Rockies have a record of 3-7-0 ATS over their last 10 games.

Rockies Recent Stats

Rockies Player Insights

• Hunter Goodman paces the Rockies in home runs (30), runs batted in (88) and has a team-high batting average of .281.
• Goodman ranks 19th in homers and 27th in RBI among all batters in the big leagues.
• Goodman has collected a hit in five games in a row. During his last five outings he is batting .381 with a double, a triple, two walks and an RBI.
• Moniak is hitting .272 with 18 doubles, eight triples, 24 home runs and 21 walks.
• Moniak ranks 49th overall in homers and 86th in RBI this year.
• Jordan Beck is batting .267 with 26 doubles, five triples, 15 home runs and 42 walks.
• Tyler Freeman has 20 doubles, two triples, two home runs and 34 walks while batting .281.

Rockies Team Props

Angels vs. Rockies Highlights | MLB on FOX

Check out the best highlights between the Los Angeles Angels and the Colorado Rockies.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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