Virginia vs. North Carolina Prediction, Odds, Picks - October 25, 2025

Updated Oct. 25, 2025 9:04 a.m. ET

FOX Sports

ACC opponents square off when the No. 16 Virginia Cavaliers (6-1) visit the North Carolina Tar Heels (2-4) on Saturday, October 25, 2025 at Kenan Stadium. Virginia is favored by 10.5 points. The contest's point total is 51.5.

Last time around, the Cavaliers defeated the Washington State Cougars, with 22-20 being the final score. Facing the California Golden Bears in their last game, the Tar Heels lost 21-18.

Keep up with college football all season on FOX Sports.

Virginia vs. North Carolina Game Information & Odds

When: Saturday, October 25, 2025 at 12 p.m. ET
Location: Kenan Stadium in Chapel Hill, North Carolina
TV: ACC Network
Live Box Score on FOX Sports

Virginia vs North Carolina Betting Information updated as of October 25, 2025, 8:45 a.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Virginia	-10.5 (-111)	-392	+308	51.5	-107	-116

Virginia vs. North Carolina Prediction

Pick ATS: Virginia (-10.5)
Pick OU: Over (51.5)
Prediction: Virginia 40, North Carolina 12

Predictions are made by the Data Skrive betting model.

Learn more about the Virginia Cavaliers vs. the North Carolina Tar Heels game on FOX Sports!

Virginia vs. North Carolina Betting Insights

Per the spread and over/under, the implied score for the game is Cavaliers 31, Tar Heels 20.
The Cavaliers have a 79.7% chance to collect the win in this meeting based on the moneyline's implied probability. The Tar Heels hold a 24.5% implied probability.
Virginia has put together a 5-2-0 record against the spread this season.
North Carolina has compiled a 3-3-0 record against the spread this year.

Virginia vs. North Carolina: Head-to-Head

North Carolina owns a 3-1 record against Virginia in their last four matchups.
The two teams have gone over the total on one occasion while sharing an even 2-2 record in their matchups against the spread.
Over their last four head-to-head contests, North Carolina has put up 158 points, while Virginia has accumulated 112.

Virginia vs. North Carolina: 2025 Stats Comparison

	Virginia	North Carolina
Off. Points per Game (Rank)	40 (10)	18.7 (132)
Def. Points per Game (Rank)	23.3 (60)	25 (48)
Turnovers Allowed (Rank)	5 (12)	9 (80)
Turnovers Forced (Rank)	9 (56)	7 (89)

Virginia 2025 Key Players

Name	Position	Stats
Chandler Morris	QB	1,607 YDS (68.7%) / 11 TD / 4 INT 191 RUSH YDS / 4 RUSH TD / 27.3 RUSH YPG
J'mari Taylor	RB	512 YDS / 8 TD / 73.1 YPG / 4.7 YPC 19 REC / 102 REC YDS / 0 REC TD / 14.6 REC YPG
Cameron Ross	WR	28 REC / 329 YDS / 2 TD / 47 YPG
Trell Harris	WR	28 REC / 405 YDS / 3 TD / 57.9 YPG
Mitchell Melton	DL	27 TKL / 2 TFL / 3 SACK
Kamren Robinson	LB	32 TKL / 2 TFL / 1 SACK / 1 INT
Daniel Rickert	DL	16 TKL / 4 TFL / 4.5 SACK
Devin Neal	DB	34 TKL / 1 TFL / 0.5 SACK

North Carolina 2025 Key Players

Name	Position	Stats
Gio Lopez	QB	597 YDS (59.8%) / 3 TD / 3 INT 80 RUSH YDS / 1 RUSH TD / 16 RUSH YPG
Jordan Shipp	WR	22 REC / 253 YDS / 2 TD / 42.2 YPG
Demon June	RB	276 YDS / 1 TD / 55.2 YPG / 6.6 YPC
Benjamin Hall	RB	136 YDS / 2 TD / 27.2 YPG / 4 YPC
Andrew Simpson	LB	31 TKL / 5 TFL / 2 SACK
Kaleb Cost	DB	28 TKL / 1 TFL / 1 INT / 1 PD
Mikai Gbayor	LB	20 TKL / 1 TFL / 1 SACK
Khmori House	LB	32 TKL / 1 TFL