Virginia Tech vs. Vanderbilt Prediction, Odds, Picks - September 6, 2025

The Virginia Tech Hokies (0-1) are small favorites (-2.5) against the Vanderbilt Commodores (1-0) on Saturday, September 6, 2025. The contest has a 45-point over/under.

Last time around, the Hokies fell to the South Carolina Gamecocks, with 24-11 being the final score. Last time around, the Commodores defeated the Charleston Southern Buccaneers, with 45-3 being the final score.

Keep up with college football all season on FOX Sports.

Virginia Tech vs. Vanderbilt Game Information & Odds

• When: Saturday, September 6, 2025 at 7:30 p.m. ET
• Location: Lane Stadium in Blacksburg, Virginia
• TV: ACC Network
• Live Box Score on FOX Sports

Virginia Tech vs. Vanderbilt Prediction

• Pick ATS: Virginia Tech (-2.5)
  
• Pick OU: Over (45)
  
• Prediction: Virginia Tech 29, Vanderbilt 21

Predictions are made by the Data Skrive betting model.

Learn more about the Virginia Tech Hokies vs. the Vanderbilt Commodores game on FOX Sports!

Virginia Tech vs. Vanderbilt Betting Insights

• Per the spread and over/under, the implied score for the matchup is Hokies 24, Commodores 21.
• The Hokies have a 56.1% chance to collect the win in this meeting based on the moneyline's implied probability. The Commodores hold a 48.1% implied probability.
• Virginia Tech has not won against the spread this season in one games with a spread.
• Vanderbilt has covered once in one games with a spread this year.

Virginia Tech vs. Vanderbilt: 2025 Stats Comparison

Virginia Tech 2025 Key Players

Vanderbilt 2025 Key Players

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

Want great stories delivered right to your inbox?

Create or log in to your FOX Sports account, follow leagues, teams and players to receive a personalized newsletter daily.

FOLLOW Follow your favorites to personalize your FOX Sports experience

Virginia Tech Hokies

Vanderbilt Commodores

College Football