Vanderbilt vs. Kentucky Prediction, Odds, Picks - November 22, 2025

Updated Nov. 22, 2025 3:04 p.m. ET

Data Skrive

The No. 12 Vanderbilt Commodores (8-2) host the Kentucky Wildcats (5-5) on Saturday, November 22, 2025 in a matchup between SEC rivals at FirstBank Stadium. Kentucky is a 7.5-point underdog. The contest has a 54-point over/under.

In their last game, the Commodores won versus the Auburn Tigers, 45-38. The Wildcats' most recent contest was versus the Tennessee Tech Golden Eagles, and they won by a score of 42-10.

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Vanderbilt vs. Kentucky Game Information & Odds

When: Saturday, November 22, 2025 at 3:30 p.m. ET
Location: FirstBank Stadium in Nashville, Tennessee
TV: ESPN
Live Box Score on FOX Sports

Vanderbilt vs Kentucky Betting Information updated as of November 22, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Vanderbilt	-7.5 (-103)	-289	+234	54	-111	-108

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Vanderbilt vs. Kentucky Prediction

Pick ATS: Vanderbilt (-7.5)
Pick OU: Over (54)
Prediction: Vanderbilt 32, Kentucky 23

Predictions are made by the Data Skrive betting model.

Learn more about the Vanderbilt Commodores vs. the Kentucky Wildcats game on FOX Sports!

Vanderbilt vs. Kentucky Betting Insights

Per the spread and over/under, the implied score for the matchup is Commodores 31, Wildcats 23.
The Commodores have a 74.3% chance to collect the win in this contest based on the moneyline's implied probability. The Wildcats hold a 29.9% implied probability.
Vanderbilt has compiled an 8-2-0 record against the spread this season.
Kentucky has won five games against the spread this season, failing to cover five times.

Vanderbilt vs. Kentucky: Head-to-Head

The last four times Kentucky and Vanderbilt have matched up, the two teams share a split 2-2 record.
In those games versus Kentucky, the Commodores have covered three times while going over the total on one occasion.
In their last four head-to-head matchups, Kentucky has racked up 113 points versus Vanderbilt, while surrendering only 89 points.

Vanderbilt vs. Kentucky: 2025 Stats Comparison

	Vanderbilt	Kentucky
Off. Points per Game (Rank)	38.3 (13)	25.9 (84)
Def. Points per Game (Rank)	22.2 (42)	23.1 (49)
Turnovers Allowed (Rank)	9 (13)	18 (122)
Turnovers Forced (Rank)	11 (87)	13 (57)

Vanderbilt 2025 Key Players

Name	Position	Stats
Diego Pavia	QB	2,440 YDS (70%) / 21 TD / 5 INT 613 RUSH YDS / 7 RUSH TD / 61.3 RUSH YPG
Sedrick Alexander	RB	441 YDS / 8 TD / 44.1 YPG / 5 YPC 12 REC / 119 REC YDS / 4 REC TD / 13.2 REC YPG
Eli Stowers	TE	50 REC / 665 YDS / 4 TD / 66.5 YPG
Junior Sherrill	WR	35 REC / 470 YDS / 6 TD / 47 YPG
CJ Heard	DB	49 TKL / 2 TFL / 2 SACK / 1 INT
Bryan Longwell	LB	54 TKL / 4 TFL / 1 INT / 1 PD
Miles Capers	DL	26 TKL / 6 TFL / 4.5 SACK
Langston Patterson	LB	46 TKL / 1 TFL

Kentucky 2025 Key Players

Name	Position	Stats
Seth McGowan	RB	693 YDS / 12 TD / 77 YPG / 4.5 YPC 16 REC / 112 REC YDS / 0 REC TD / 14 REC YPG
Cutter Boley	QB	1,780 YDS (68.8%) / 13 TD / 8 INT 120 RUSH YDS / 2 RUSH TD / 13.3 RUSH YPG
Kendrick Law	WR	47 REC / 519 YDS / 3 TD / 51.9 YPG
Dante Dowdell	RB	528 YDS / 3 TD / 52.8 YPG / 5.2 YPC
Daveren Rayner	LB	50 TKL / 5 TFL / 2 SACK / 2 INT
Ty Bryant	DB	54 TKL / 1 TFL / 3 INT / 3 PD
Alex Afari	LB	49 TKL / 5 TFL / 2.5 SACK
Jonquis Hardaway	DB	50 TKL / 2 TFL / 1 SACK / 1 INT