Vanderbilt vs. Iowa Prediction, Odds, Picks - December 31, 2025

Updated Dec. 29, 2025 3:05 p.m. ET

Data Skrive

The ReliaQuest Bowl features a battle between the Vanderbilt Commodores (who are 4-point favorites) and the Iowa Hawkeyes on December 31, 2025 at 12 p.m. ET on ESPN. The contest has an over/under of 46.5.

The Commodores' most recent contest was versus the Tennessee Volunteers, and they won by a score of 45-24. Last time out, the Hawkeyes defeated the Nebraska Cornhuskers, with 40-16 being the final score.

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Vanderbilt vs. Iowa Game Information & Odds

When: Wednesday, December 31, 2025 at 12 p.m. ET
Location: Raymond James Stadium in Tampa, Florida
TV: ESPN
Streaming: FOX One + ESPN Bundle

Vanderbilt vs Iowa Betting Information updated as of December 29, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Vanderbilt	-4 (-110)	-211	+175	46.5	-112	-108

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Vanderbilt vs. Iowa Prediction

Pick ATS: Iowa (+4)
Pick OU: Over (46.5)
Prediction: Iowa 27, Vanderbilt 26

Predictions are made by the Data Skrive betting model.

Learn more about the Vanderbilt Commodores vs. the Iowa Hawkeyes game on FOX Sports!

Vanderbilt vs. Iowa Betting Insights

Based on the spread and over/under, the implied score for the matchup is Commodores 25, Hawkeyes 21.
The Commodores have a 67.8% chance to collect the win in this contest per the moneyline's implied probability. The Hawkeyes have a 36.4% implied probability.
Vanderbilt has compiled a 10-2-0 record against the spread this season.
Iowa has covered eight times in 12 games with a spread this year.

Vanderbilt vs. Iowa: 2025 Stats Comparison

	Vanderbilt	Iowa
Off. Points per Game (Rank)	39.4 (12)	28.9 (67)
Def. Points per Game (Rank)	21.9 (34)	15.2 (6)
Turnovers Allowed (Rank)	12 (18)	11 (12)
Turnovers Forced (Rank)	14 (85)	14 (85)

Vanderbilt 2025 Key Players

Name	Position	Stats
Diego Pavia	QB	3,192 YDS (71.2%) / 27 TD / 8 INT 826 RUSH YDS / 9 RUSH TD / 68.8 RUSH YPG
Sedrick Alexander	RB	563 YDS / 11 TD / 46.9 YPG / 5.5 YPC 16 REC / 181 REC YDS / 4 REC TD / 16.5 REC YPG
Junior Sherrill	WR	46 REC / 661 YDS / 7 TD / 55.1 YPG
Tre Richardson	WR	41 REC / 683 YDS / 6 TD / 62.1 YPG
CJ Heard	DB	60 TKL / 2 TFL / 2 SACK / 1 INT
Bryan Longwell	LB	63 TKL / 6 TFL / 1 SACK / 1 INT
Miles Capers	DL	32 TKL / 6 TFL / 4.5 SACK
Nicholas Rinaldi	LB	38 TKL / 5 TFL / 3.5 SACK

Iowa 2025 Key Players

Name	Position	Stats
Mark Gronowski	QB	1,529 YDS (62.5%) / 8 TD / 6 INT 491 RUSH YDS / 15 RUSH TD / 40.9 RUSH YPG
Kamari Moulton	RB	783 YDS / 4 TD / 78.3 YPG / 5 YPC 15 REC / 95 REC YDS / 0 REC TD / 11.9 REC YPG
Kaden Wetjen	WR	20 REC / 151 YDS / 1 TD / 13.7 YPG
Xavier Williams	RB	260 YDS / 3 TD / 28.9 YPG / 5.9 YPC
Karson Sharar	LB	76 TKL / 7 TFL / 2 SACK
Zach Lutmer	DB	66 TKL / 5 TFL / 1 SACK / 3 INT
Xavier Nwankpa	DB	68 TKL / 1 TFL / 1 INT / 1 PD
Koen Entringer	DB	68 TKL / 3 TFL