UConn vs. Buffalo Prediction, Odds, Picks - September 27, 2025

Updated Sep. 27, 2025 3:04 p.m. ET

FOX Sports

The Buffalo Bulls (2-2) will attempt to prove oddsmakers wrong when they take on the UConn Huskies (2-2) on Saturday, September 27, 2025 as 3-point underdogs. The point total is set at 51.

The Huskies won versus the Ball State Cardinals in their last game, 31-25. The Bulls lost to the Troy Trojans, 21-17, in their most recent contest.

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UConn vs. Buffalo Game Information & Odds

When: Saturday, September 27, 2025 at 3:30 p.m. ET
Location: UB Stadium in Buffalo, New York
TV: ESPN+
Live Box Score on FOX Sports

UConn vs Buffalo Betting Information updated as of September 27, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
UConn	-3 (-110)	-156	+131	51	-110	-110

UConn vs. Buffalo Prediction

Pick ATS: UConn (-3)
Pick OU: Over (51)
Prediction: UConn 30, Buffalo 23

Predictions are made by the Data Skrive betting model.

Learn more about the UConn Huskies vs. the Buffalo Bulls game on FOX Sports!

UConn vs. Buffalo Betting Insights

Per the spread and over/under, the implied score for the tilt is Huskies 27, Bulls 24.
The Huskies have a 60.9% chance to win this contest based on the moneyline's implied probability. The Bulls hold a 43.3% implied probability.
UConn has covered once in four matchups with a spread this season.
Buffalo has won two games against the spread this season.

UConn vs. Buffalo: 2025 Stats Comparison

	UConn	Buffalo
Off. Points per Game (Rank)	37.8 (21)	25.8 (81)
Def. Points per Game (Rank)	27.3 (103)	19.5 (55)
Turnovers Allowed (Rank)	0 (1)	5 (74)
Turnovers Forced (Rank)	3 (96)	5 (50)

UConn 2025 Key Players

Name	Position	Stats
Cam Edwards	RB	500 YDS / 5 TD / 125 YPG / 6.8 YPC 2 REC / 45 REC YDS / 0 REC TD / 22.5 REC YPG
Joe Fagnano	QB	1,046 YDS (66.2%) / 6 TD / 0 INT 1 RUSH YDS / 1 RUSH TD / 0.3 RUSH YPG
Skyler Bell	WR	36 REC / 445 YDS / 3 TD / 111.3 YPG
Reymello Murphy	WR	13 REC / 134 YDS / 2 TD / 33.5 YPG
Bryun Parham	LB	28 TKL / 5 TFL / 5.5 SACK
Tyquan King	LB	19 TKL / 3 TFL / 3 SACK
Oumar Diomande	LB	23 TKL / 2 TFL / 2 SACK
D'Mon Brinson	DB	17 TKL / 1 TFL / 1 INT / 1 PD

Buffalo 2025 Key Players

Name	Position	Stats
Ta'Quan Roberson	QB	662 YDS (62.1%) / 5 TD / 2 INT 165 RUSH YDS / 2 RUSH TD / 41.3 RUSH YPG
Al-Jay Henderson	RB	274 YDS / 4 TD / 68.5 YPG / 3.8 YPC 13 REC / 115 REC YDS / 0 REC TD / 38.3 REC YPG
Victor Snow	WR	16 REC / 206 YDS / 3 TD / 51.5 YPG
Nik McMillan	WR	11 REC / 154 YDS / 1 TD / 38.5 YPG
Khalil Murdock	LB	34 TKL / 3 TFL / 2 SACK
Dion Crawford	LB	27 TKL / 2 TFL / 2 SACK
Mitchell Gonser	LB	14 TKL / 2 TFL / 1 SACK / 1 INT
Saveon Brown	LB	14 TKL / 3 TFL / 2 SACK