South Florida vs. Memphis Prediction, Odds, Picks - October 25, 2025

Updated Oct. 25, 2025 9:04 a.m. ET

Data Skrive

The Memphis Tigers (6-1) and the 24th-ranked scoring defense will host the No. 18 South Florida Bulls (6-1) and the seventh-ranked scoring offense on Saturday, October 25, 2025. The Tigers are 6-point underdogs. The contest has a 58.5-point over/under.

Against the Florida Atlantic Owls in their last game, the Bulls won 48-13. In their last contest, the Tigers lost versus the UAB Blazers, 31-24.

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South Florida vs. Memphis Game Information & Odds

When: Saturday, October 25, 2025 at 12 p.m. ET
Location: Simmons Bank Liberty Stadium in Memphis, Tennessee
TV: ESPN2
Live Box Score on FOX Sports

South Florida vs Memphis Betting Information updated as of October 25, 2025, 8:45 a.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
South Florida	-6 (-110)	-220	+181	58.5	-108	-115

South Florida vs. Memphis Prediction

Pick ATS: South Florida (-6)
Pick OU: Over (58.5)
Prediction: South Florida 34, Memphis 26

Predictions are made by the Data Skrive betting model.

Learn more about the South Florida Bulls vs. the Memphis Tigers game on FOX Sports!

South Florida vs. Memphis Betting Insights

Per the spread and over/under, the implied score for the matchup is Bulls 32, Tigers 26.
The Bulls have a 68.8% chance to win this game based on the moneyline's implied probability. The Tigers hold a 35.6% implied probability.
South Florida has won five games against the spread this season, while failing to cover or pushing twice.
Memphis has won six games against the spread this year, failing to cover once.

South Florida vs. Memphis: Head-to-Head

In their last two head-to-head bouts, Memphis has defeated South Florida two times.
In their last two matchups, each team has covered one time with those contests hitting the over on the total on one occasion.
Over their last two head-to-head contests, Memphis has scored 80 points, while South Florida has accumulated 53.

South Florida vs. Memphis: 2025 Stats Comparison

	South Florida	Memphis
Off. Points per Game (Rank)	41.7 (7)	38.1 (15)
Def. Points per Game (Rank)	23 (58)	18.3 (26)
Turnovers Allowed (Rank)	10 (90)	8 (56)
Turnovers Forced (Rank)	17 (1)	14 (10)

South Florida 2025 Key Players

Name	Position	Stats
Byrum Brown	QB	1,695 YDS (63.4%) / 16 TD / 5 INT 475 RUSH YDS / 6 RUSH TD / 67.9 RUSH YPG
Chas Nimrod	WR	23 REC / 466 YDS / 3 TD / 77.7 YPG
Keshaun Singleton	WR	22 REC / 363 YDS / 3 TD / 51.9 YPG
Jeremiah Koger	WR	12 REC / 259 YDS / 4 TD / 51.8 YPG
Mac Harris	LB	55 TKL / 5 TFL / 5.5 SACK / 1 INT
Jhalyn Shuler	LB	61 TKL / 4 TFL / 1 SACK / 1 INT
Jarvis Lee Jr.	DB	28 TKL / 3 TFL / 2 INT / 2 PD
Fred Gaskin	DB	26 TKL / 1 TFL / 1 SACK / 1 INT

Memphis 2025 Key Players

Name	Position	Stats
Brendon Lewis	QB	1,337 YDS (69.5%) / 8 TD / 4 INT 435 RUSH YDS / 7 RUSH TD / 62.1 RUSH YPG
Sutton Smith	RB	480 YDS / 6 TD / 68.6 YPG / 6.4 YPC
Gregroy Desrosiers	RB	389 YDS / 5 TD / 77.8 YPG / 6.8 YPC 13 REC / 81 REC YDS / 1 REC TD / 20.3 REC YPG
Cortez Braham	WR	29 REC / 491 YDS / 5 TD / 70.1 YPG
Sam Brumfield	LB	35 TKL / 7 TFL / 3.5 SACK / 1 INT
Drue Watts	DB	40 TKL / 6 TFL / 1 SACK
DeMarco Ward	LB	32 TKL / 1 TFL / 2 INT / 2 PD
Chris Bracy	DB	25 TKL / 5 TFL / 1 INT / 1 PD