Pittsburgh vs. Central Michigan Prediction, Odds, Picks - September 6, 2025

Updated Sep. 6, 2025 9:04 a.m. ET

FOX Sports

The Pittsburgh Panthers (1-0) are an overwhelming 21.5-point favorite heading into their matchup on Saturday, September 6, 2025 against the Central Michigan Chippewas (1-0). The game has a point total set at 49.5.

In their most recent action, the Panthers won against the Duquesne Dukes, 61-9. Last time around, the Chippewas defeated the San Jose State Spartans, with 16-14 being the final score.

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Pittsburgh vs. Central Michigan Game Information & Odds

When: Saturday, September 6, 2025 at 12 p.m. ET
Location: Acrisure Stadium in Pittsburgh, Pennsylvania
TV: ESPNU
Live Box Score on FOX Sports

Pittsburgh vs Central Michigan Betting Information updated as of September 6, 2025, 8:45 a.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Pittsburgh	-21.5 (-115)	-2041	+1016	49.5	-105	-115

Pittsburgh vs. Central Michigan Prediction

Pick ATS: Pittsburgh (-21.5)
Pick OU: Over (49.5)
Prediction: Pittsburgh 38, Central Michigan 16

Predictions are made by the Data Skrive betting model.

Learn more about the Pittsburgh Panthers vs. the Central Michigan Chippewas game on FOX Sports!

Pittsburgh vs. Central Michigan Betting Insights

Based on the spread and over/under, the implied score for the tilt is Panthers 36, Chippewas 14.
The Panthers have a 95.3% chance to claim victory in this game per the moneyline's implied probability. The Chippewas hold a 9.0% implied probability.
Pittsburgh has covered in its only game with a spread this season.
Central Michigan has put together a perfect 1-0-0 record against the spread this season.

Pittsburgh vs. Central Michigan: 2025 Stats Comparison

	Pittsburgh	Central Michigan
Off. Points per Game (Rank)	61 (11)	16 (103)
Def. Points per Game (Rank)	9 (33)	14 (55)
Turnovers Allowed (Rank)	1 (55)	0 (1)
Turnovers Forced (Rank)	0 (94)	3 (8)

Pittsburgh 2025 Key Players

Name	Position	Stats
Eli Holstein	QB	215 YDS (65.2%) / 4 TD / 1 INT 41 RUSH YDS / 0 RUSH TD / 41 RUSH YPG
Desmond Reid	RB	66 YDS / 1 TD / 66 YPG / 8.3 YPC
Cataurus Hicks	WR	4 REC / 55 YDS / 2 TD / 55 YPG
Bryce Yates	WR	2 REC / 69 YDS / 1 TD / 69 YPG
Kyle Louis	LB	6 TKL / 3 TFL / 2 SACK
Cameron Lindsey	LB	3 TKL / 1 TFL / 1 SACK
Joseph Zelinsky	DL	2 TKL / 1 TFL / 1 SACK
Cruce Brookins	DB	5 TKL / 0 TFL

Central Michigan 2025 Key Players

Name	Position	Stats
Trey Cornist	RB	99 YDS / 1 TD / 99 YPG / 7.6 YPC
Nahree Biggins	RB	102 YDS / 0 TD / 102 YPG / 5.7 YPC
Tommy McIntosh	WR	2 REC / 61 YDS / 0 TD / 61 YPG
Angel Flores	QB	59 YDS (100%) / 0 TD / 0 INT 30 RUSH YDS / 0 RUSH TD / 30 RUSH YPG
Michael Heldman	DL	6 TKL / 0 TFL / 1 SACK
Elijah Rikard	DB	2 TKL / 0 TFL / 1 INT / 1 PD
Kalen Carroll	DB	7 TKL / 0 TFL
Brenden Deasfernandes	DB	1 TKL / 0 TFL / 1 INT / 1 PD