Penn State vs. Nebraska Prediction, Odds, Picks - November 22, 2025

Updated Nov. 22, 2025 3:04 p.m. ET

Data Skrive

Two of the nation's best pass defenses square off when the Penn State Nittany Lions (4-6) bring college football's 13th-ranked pass defense into a matchup with the Nebraska Cornhuskers (7-3), who have the No. 3 passing defense, on Saturday, November 22, 2025. The Nittany Lions are 7.5-point favorites. The total has been set at 45.5 points for this game.

The Nittany Lions won against the Michigan State Spartans in their most recent game, 28-10. Last time out, the Cornhuskers defeated the UCLA Bruins, with 28-21 being the final score.

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Penn State vs. Nebraska Game Information & Odds

When: Saturday, November 22, 2025 at 7 p.m. ET
Location: West Shore Home Field at Beaver Stadium in University Park, Pennsylvania
TV: NBC
Live Box Score on FOX Sports

Penn State vs Nebraska Betting Information updated as of November 22, 2025, 12:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Penn State	-7.5 (-110)	-302	+241	45.5	-106	-114

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Penn State vs. Nebraska Prediction

Pick ATS: Nebraska (+7.5)
Pick OU: Over (45.5)
Prediction: Penn State 27, Nebraska 24

Predictions are made by the Data Skrive betting model.

Learn more about the Penn State Nittany Lions vs. the Nebraska Cornhuskers game on FOX Sports!

Penn State vs. Nebraska Betting Insights

Per the spread and over/under, the implied score for the tilt is Nittany Lions 26, Cornhuskers 19.
The Nittany Lions have a 75.1% chance to collect the win in this contest based on the moneyline's implied probability. The Cornhuskers have a 29.3% implied probability.
Penn State is 3-7-0 ATS this season.
Nebraska has covered four times in 10 games with a spread this year.

Penn State vs. Nebraska: 2025 Stats Comparison

	Penn State	Nebraska
Off. Points per Game (Rank)	30.4 (54)	32.5 (38)
Def. Points per Game (Rank)	21.1 (34)	19.9 (25)
Turnovers Allowed (Rank)	10 (25)	9 (13)
Turnovers Forced (Rank)	12 (72)	12 (72)

Penn State 2025 Key Players

Name	Position	Stats
Kaytron Allen	RB	917 YDS / 12 TD / 91.7 YPG / 5.6 YPC
Nicholas Singleton	RB	419 YDS / 9 TD / 41.9 YPG / 3.9 YPC 19 REC / 145 REC YDS / 1 REC TD / 14.5 REC YPG
Drew Allar	QB	1,100 YDS (64.8%) / 8 TD / 3 INT 172 RUSH YDS / 1 RUSH TD / 28.7 RUSH YPG
Devonte Ross	WR	25 REC / 360 YDS / 5 TD / 36 YPG
Amare Campbell	LB	74 TKL / 6 TFL / 2.5 SACK
Zakee Wheatley	DB	64 TKL / 2 TFL / 1 INT / 1 PD
Dani Dennis-Sutton	DL	31 TKL / 7 TFL / 5 SACK
Dominic DeLuca	LB	44 TKL / 4 TFL / 1 SACK

Nebraska 2025 Key Players

Name	Position	Stats
Emmett Johnson	RB	1,131 YDS / 11 TD / 113.1 YPG / 5.6 YPC 36 REC / 300 REC YDS / 3 REC TD / 30 REC YPG
Dylan Raiola	QB	2,002 YDS (72.4%) / 18 TD / 6 INT
Nyziah Hunter	WR	41 REC / 592 YDS / 5 TD / 59.2 YPG
Dane Key	WR	28 REC / 360 YDS / 5 TD / 36 YPG
Javin Wright	LB	70 TKL / 6 TFL / 1.5 SACK / 1 INT
DeShon Singleton	DB	51 TKL / 1 TFL / 2 INT / 3 PD
Vincent Shavers Jr.	LB	39 TKL / 6 TFL / 1 SACK
Williams Nwaneri	DL	26 TKL / 4 TFL / 2.5 SACK