Oregon vs. Iowa Prediction, Odds, Picks - November 8, 2025

Updated Nov. 8, 2025 3:04 p.m. ET

Data Skrive

The No. 6 Oregon Ducks (7-1) bring the sixth-ranked scoring offense in college football into a matchup with the Iowa Hawkeyes (6-2), who have the No. 4 scoring defense, on Saturday, November 8, 2025. The Ducks are 5.5-point favorites. A total of 41.5 points has been set for this game.

The Ducks beat the Wisconsin Badgers, 21-7, in their most recent game. The Hawkeyes beat the Minnesota Golden Gophers, 41-3, in their last game.

Keep up with college football all season on FOX Sports.

Oregon vs. Iowa Game Information & Odds

When: Saturday, November 8, 2025 at 3:30 p.m. ET
Location: Kinnick Stadium in Iowa City, Iowa
TV: CBS
Live Box Score on FOX Sports

Oregon vs Iowa Betting Information updated as of November 8, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Oregon	-5.5 (-107)	-201	+166	41.5	-109	-111

This page may contain affiliate links to legal sports betting partners. If you sign up or place a wager, FOX Sports may be compensated. Read more about Sports Betting on FOX Sports.

Oregon vs. Iowa Prediction

Pick ATS: Iowa (+5.5)
Pick OU: Over (41.5)
Prediction: Oregon 25, Iowa 24

Predictions are made by the Data Skrive betting model.

Learn more about the Oregon Ducks vs. the Iowa Hawkeyes game on FOX Sports!

Oregon vs. Iowa Betting Insights

Based on the spread and over/under, the implied score for the tilt is Ducks 24, Hawkeyes 18.
The Ducks have a 66.8% chance to win this meeting per the moneyline's implied probability. The Hawkeyes hold a 37.6% implied probability.
Oregon has won four games against the spread this season, while failing to cover four times.
Iowa has covered five times in eight matchups with a spread this year.

Oregon vs. Iowa: 2025 Stats Comparison

	Oregon	Iowa
Off. Points per Game (Rank)	41.3 (12)	31.3 (66)
Def. Points per Game (Rank)	13.5 (5)	13.1 (4)
Turnovers Allowed (Rank)	6 (5)	6 (5)
Turnovers Forced (Rank)	11 (56)	11 (56)

Oregon 2025 Key Players

Name	Position	Stats
Dante Moore	QB	1,772 YDS (71.4%) / 19 TD / 4 INT 131 RUSH YDS / 0 RUSH TD / 16.4 RUSH YPG
Jordon Davison	RB	352 YDS / 10 TD / 44 YPG / 7 YPC
Noah Whittington	RB	433 YDS / 4 TD / 72.2 YPG / 8.5 YPC 7 REC / 34 REC YDS / 1 REC TD / 11.3 REC YPG
Dakorien Moore	WR	28 REC / 443 YDS / 3 TD / 55.4 YPG
Bryce Boettcher	LB	58 TKL / 0 TFL / 1 INT / 1 PD
Teitum Tuioti	LB	35 TKL / 5 TFL / 3.5 SACK
Aaron Flowers	DB	37 TKL / 1 TFL / 1 INT / 1 PD
Bear Alexander	DL	33 TKL / 4 TFL / 0.5 SACK

Iowa 2025 Key Players

Name	Position	Stats
Mark Gronowski	QB	946 YDS (64.8%) / 4 TD / 4 INT 313 RUSH YDS / 11 RUSH TD / 39.1 RUSH YPG
Kamari Moulton	RB	435 YDS / 2 TD / 72.5 YPG / 5.3 YPC 11 REC / 81 REC YDS / 0 REC TD / 20.3 REC YPG
Kaden Wetjen	WR	16 REC / 129 YDS / 1 TD / 18.4 YPG
Xavier Williams	RB	249 YDS / 3 TD / 41.5 YPG / 6.6 YPC
Max Llewellyn	DL	15 TKL / 7 TFL / 6 SACK
Zach Lutmer	DB	41 TKL / 2 TFL / 1 SACK / 2 INT
Aaron Graves	DL	27 TKL / 5 TFL / 4 SACK / 1 INT
Xavier Nwankpa	DB	42 TKL / 0 TFL / 1 INT / 1 PD