Oregon vs. Indiana Prediction, Odds, Picks - October 11, 2025

Updated Oct. 11, 2025 3:05 p.m. ET

Data Skrive

The No. 3 Oregon Ducks (5-0) and the sixth-ranked scoring offense will meet the No. 7 Indiana Hoosiers (5-0) and the third-ranked scoring defense on Saturday, October 11, 2025. The Ducks are favored by 7 points in the outing. The contest's over/under is 52.5.

Last time around, the Ducks defeated the Penn State Nittany Lions, with 30-24 being the final score. The Hoosiers' last game was versus the Iowa Hawkeyes, and they won by a score of 20-15.

Keep up with college football all season on FOX Sports.

Oregon vs. Indiana Game Information & Odds

When: Saturday, October 11, 2025 at 3:30 p.m. ET
Location: Autzen Stadium in Eugene, Oregon
TV: CBS
Live Box Score on FOX Sports

Oregon vs Indiana Betting Information updated as of October 11, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Oregon	-7 (-111)	-283	+230	52.5	-110	-110

Oregon vs. Indiana Prediction

Pick ATS: Indiana (+7)
Pick OU: Over (52.5)
Prediction: Indiana 37, Oregon 17

Predictions are made by the Data Skrive betting model.

Learn more about the Oregon Ducks vs. the Indiana Hoosiers game on FOX Sports!

Oregon vs. Indiana Betting Insights

Based on the spread and over/under, the implied score for the game is Ducks 30, Hoosiers 23.
The Ducks have a 73.9% chance to claim victory in this contest based on the moneyline's implied probability. The Hoosiers hold a 30.3% implied probability.
Oregon has put together a 3-2-0 ATS record so far this year.
Indiana has won three games against the spread this season, failing to cover twice.

Oregon vs. Indiana: 2025 Stats Comparison

	Oregon	Indiana
Off. Points per Game (Rank)	46.6 (12)	47.8 (9)
Def. Points per Game (Rank)	12.2 (6)	9.6 (3)
Turnovers Allowed (Rank)	1 (2)	2 (6)
Turnovers Forced (Rank)	6 (70)	8 (42)

Oregon 2025 Key Players

Name	Position	Stats
Dante Moore	QB	1,210 YDS (74.6%) / 14 TD / 1 INT 122 RUSH YDS / 0 RUSH TD / 24.4 RUSH YPG
Dakorien Moore	WR	19 REC / 296 YDS / 2 TD / 59.2 YPG
Jordon Davison	RB	91 YDS / 7 TD / 18.2 YPG / 4 YPC
Dierre Hill Jr.	RB	270 YDS / 2 TD / 54 YPG / 10.4 YPC 2 REC / 12 REC YDS / 1 REC TD / 6 REC YPG
Teitum Tuioti	LB	23 TKL / 4 TFL / 2.5 SACK
Bryce Boettcher	LB	34 TKL / 0 TFL / 1 INT / 1 PD
Matayo Uiagalelei	LB	11 TKL / 5 TFL / 4 SACK
Dillon Thieneman	DB	20 TKL / 0 TFL / 1 INT / 1 PD

Indiana 2025 Key Players

Name	Position	Stats
Fernando Mendoza	QB	1,208 YDS (73%) / 16 TD / 1 INT 102 RUSH YDS / 2 RUSH TD / 20.4 RUSH YPG
Omar Cooper Jr.	WR	23 REC / 432 YDS / 6 TD / 86.4 YPG
Elijah Sarratt	WR	30 REC / 388 YDS / 6 TD / 77.6 YPG
Kaelon Black	RB	344 YDS / 2 TD / 68.8 YPG / 6.3 YPC
Isaiah Jones	LB	19 TKL / 6 TFL / 3.5 SACK
Louis Moore	DB	23 TKL / 2 TFL / 2 INT / 2 PD
Tyrique Tucker	DL	17 TKL / 4 TFL / 3 SACK
Kellan Wyatt	DL	20 TKL / 5 TFL / 1 SACK