Oklahoma vs. Missouri Prediction, Odds, Picks - November 22, 2025

Updated Nov. 22, 2025 9:04 a.m. ET

FOX Sports

The No. 23 Missouri Tigers (7-3) and the sixth-ranked run offense will take the field against the No. 8 Oklahoma Sooners (8-2) and the fourth-ranked run defense on Saturday, November 22, 2025. The Sooners are favored by 5.5 points in the outing. A total of 42.5 points has been set for this matchup.

The Sooners' last contest was against the Alabama Crimson Tide, and they won by a score of 23-21. Last time around, the Tigers defeated the Mississippi State Bulldogs, with 49-27 being the final score.

Keep up with college football all season on FOX Sports.

Oklahoma vs. Missouri Game Information & Odds

When: Saturday, November 22, 2025 at 12 p.m. ET
Location: Gaylord Family Oklahoma Memorial Stadium in Norman, Oklahoma
TV: ABC
Live Box Score on FOX Sports

Oklahoma vs Missouri Betting Information updated as of November 22, 2025, 8:45 a.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Oklahoma	-5.5 (-112)	-228	+187	42.5	-115	-106

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Oklahoma vs. Missouri Prediction

Pick ATS: Oklahoma (-5.5)
Pick OU: Over (42.5)
Prediction: Oklahoma 30, Missouri 18

Predictions are made by the Data Skrive betting model.

Learn more about the Oklahoma Sooners vs. the Missouri Tigers game on FOX Sports!

Oklahoma vs. Missouri Betting Insights

Based on the spread and over/under, the implied score for the matchup is Sooners 24, Tigers 18.
The Sooners have a 69.5% chance to claim victory in this meeting per the moneyline's implied probability. The Tigers have a 34.8% implied probability.
Oklahoma has covered six times in 10 chances against the spread this season.
Missouri has put together a 6-4-0 ATS record so far this season.

Oklahoma vs. Missouri: 2025 Stats Comparison

	Oklahoma	Missouri
Off. Points per Game (Rank)	28.3 (65)	34.9 (23)
Def. Points per Game (Rank)	14.8 (8)	19.9 (25)
Turnovers Allowed (Rank)	12 (54)	13 (69)
Turnovers Forced (Rank)	10 (100)	11 (87)

Oklahoma 2025 Key Players

Name	Position	Stats
John Mateer	QB	2,087 YDS (63.9%) / 8 TD / 7 INT 329 RUSH YDS / 7 RUSH TD / 36.6 RUSH YPG
Isaiah Sategna	WR	53 REC / 718 YDS / 5 TD / 71.8 YPG
Xavier Robinson	RB	366 YDS / 4 TD / 52.3 YPG / 5.9 YPC 10 REC / 73 REC YDS / 1 REC TD / 10.4 REC YPG
Tory Blaylock	RB	404 YDS / 4 TD / 40.4 YPG / 4.1 YPC
R Mason Thomas	DL	21 TKL / 5 TFL / 6.5 SACK
Taylor Wein	DL	25 TKL / 10 TFL / 4.5 SACK / 1 INT
Kip Lewis	LB	43 TKL / 6 TFL / 3 SACK
Robert Spears-Jennings	DB	35 TKL / 1 TFL / 1 INT / 1 PD

Missouri 2025 Key Players

Name	Position	Stats
Ahmad Hardy	RB	1,346 YDS / 15 TD / 134.6 YPG / 6.8 YPC
Beau Pribula	QB	1,690 YDS (69.6%) / 11 TD / 7 INT 220 RUSH YDS / 5 RUSH TD / 27.5 RUSH YPG
Jamal Roberts	RB	583 YDS / 4 TD / 58.3 YPG / 6.3 YPC 13 REC / 114 REC YDS / 1 REC TD / 14.3 REC YPG
Kevin Coleman Jr.	WR	56 REC / 600 YDS / 1 TD / 60 YPG
Zion Young	DL	31 TKL / 8 TFL / 5.5 SACK
Josiah Trotter	LB	60 TKL / 8 TFL / 1 SACK
Damon Wilson Jr.	DL	15 TKL / 5 TFL / 6.5 SACK / 1 INT
Khalil Jacobs	LB	36 TKL / 4 TFL / 3 SACK