Ohio State vs. Wisconsin Prediction, Odds, Picks - October 18, 2025

Updated Oct. 18, 2025 3:04 p.m. ET

FOX Sports

A pair of the nation's toughest rushing defenses square off when the No. 1 Ohio State Buckeyes (6-0) take college football's ninth-ranked rushing defense into a matchup with the Wisconsin Badgers (2-4), who have the No. 18 rushing defense, on Saturday, October 18, 2025. The Buckeyes are double-digit, 25.5-point favorites. The total has been set at 41.5 points for this game.

Last time around, the Buckeyes defeated the Illinois Fighting Illini, with 34-16 being the final score. The Badgers lost to the Iowa Hawkeyes, 37-0, in their most recent contest.

Keep up with college football all season on FOX Sports.

Ohio State vs. Wisconsin Game Information & Odds

When: Saturday, October 18, 2025 at 3:30 p.m. ET
Location: Camp Randall Stadium in Madison, Wisconsin
TV: CBS
Live Box Score on FOX Sports

Ohio State vs Wisconsin Betting Information updated as of October 18, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Ohio State	-25.5 (-105)	-3846	+1570	41.5	-103	-117

Ohio State vs. Wisconsin Prediction

Pick ATS: Ohio State (-25.5)
Pick OU: Under (41.5)
Prediction: Ohio State 36, Wisconsin 3

Predictions are made by the Data Skrive betting model.

Learn more about the Ohio State Buckeyes vs. the Wisconsin Badgers game on FOX Sports!

Ohio State vs. Wisconsin Betting Insights

Based on the spread and over/under, the implied score for the game is Buckeyes 34, Badgers 8.
The Buckeyes have a 97.5% chance to collect the win in this contest based on the moneyline's implied probability. The Badgers have a 6.0% implied probability.
Ohio State is 5-1-0 ATS this season.
Wisconsin has covered twice in six games with a spread this year.

Ohio State vs. Wisconsin: Head-to-Head

Ohio State holds a 2-0 record against Wisconsin in their last two matchups.
In their past two matchups, each team has covered one time with those contests hitting the over on the point total on one occasion.
In their last two head-to-head matchups, Ohio State has scored 76 points versus Wisconsin, while allowing only 31 points.

Ohio State vs. Wisconsin: 2025 Stats Comparison

	Ohio State	Wisconsin
Off. Points per Game (Rank)	36.8 (26)	15.5 (131)
Def. Points per Game (Rank)	6.8 (1)	22.7 (55)
Turnovers Allowed (Rank)	4 (11)	10 (105)
Turnovers Forced (Rank)	7 (72)	4 (117)

Ohio State 2025 Key Players

Name	Position	Stats
Julian Sayin	QB	1,479 YDS (78.4%) / 15 TD / 3 INT
Jeremiah Smith	WR	40 REC / 505 YDS / 7 TD / 84.2 YPG
Carnell Tate	WR	28 REC / 476 YDS / 4 TD / 79.3 YPG
CJ Donaldson	RB	237 YDS / 6 TD / 39.5 YPG / 4.1 YPC 5 REC / 30 REC YDS / 1 REC TD / 7.5 REC YPG
Caden Curry	DL	30 TKL / 9 TFL / 6 SACK
Arvell Reese	LB	38 TKL / 4 TFL / 4.5 SACK
Kayden McDonald	DL	26 TKL / 5 TFL / 3 SACK
Sonny Styles	LB	39 TKL / 1 TFL

Wisconsin 2025 Key Players

Name	Position	Stats
Vinny Anthony	WR	24 REC / 274 YDS / 1 TD / 45.7 YPG
Danny O'Neil	QB	640 YDS (70.6%) / 5 TD / 5 INT 24 RUSH YDS / 1 RUSH TD / 6 RUSH YPG
Dilin Jones	RB	286 YDS / 2 TD / 47.7 YPG / 4.2 YPC
Lance Mason	TE	18 REC / 236 YDS / 2 TD / 39.3 YPG
Christian Alliegro	LB	36 TKL / 4 TFL / 2 SACK
Tackett Curtis	LB	22 TKL / 1 TFL / 1 SACK
Mason Reiger	LB	17 TKL / 2 TFL / 1.5 SACK
Sebastian Cheeks	LB	13 TKL / 2 TFL / 1 SACK