Ohio State vs. Wisconsin Prediction, Odds, Picks - October 18, 2025

A pair of the nation's toughest rushing defenses square off when the No. 1 Ohio State Buckeyes (6-0) take college football's ninth-ranked rushing defense into a matchup with the Wisconsin Badgers (2-4), who have the No. 18 rushing defense, on Saturday, October 18, 2025. The Buckeyes are double-digit, 25.5-point favorites. The total has been set at 41.5 points for this game.

Last time around, the Buckeyes defeated the Illinois Fighting Illini, with 34-16 being the final score. The Badgers lost to the Iowa Hawkeyes, 37-0, in their most recent contest.

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Ohio State vs. Wisconsin Game Information & Odds

• When: Saturday, October 18, 2025 at 3:30 p.m. ET
• Location: Camp Randall Stadium in Madison, Wisconsin
• TV: CBS
• Live Box Score on FOX Sports

Ohio State vs. Wisconsin Prediction

• Pick ATS: Ohio State (-25.5)
  
• Pick OU: Under (41.5)
  
• Prediction: Ohio State 36, Wisconsin 3

Predictions are made by the Data Skrive betting model.

Learn more about the Ohio State Buckeyes vs. the Wisconsin Badgers game on FOX Sports!

Ohio State vs. Wisconsin Betting Insights

• Based on the spread and over/under, the implied score for the game is Buckeyes 34, Badgers 8.
• The Buckeyes have a 97.5% chance to collect the win in this contest based on the moneyline's implied probability. The Badgers have a 6.0% implied probability.
• Ohio State is 5-1-0 ATS this season.
• Wisconsin has covered twice in six games with a spread this year.

Ohio State vs. Wisconsin: Head-to-Head

• Ohio State holds a 2-0 record against Wisconsin in their last two matchups.
• In their past two matchups, each team has covered one time with those contests hitting the over on the point total on one occasion.
• In their last two head-to-head matchups, Ohio State has scored 76 points versus Wisconsin, while allowing only 31 points.

Ohio State vs. Wisconsin: 2025 Stats Comparison

Ohio State 2025 Key Players

Wisconsin 2025 Key Players

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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