Ohio State vs. Washington Prediction, Odds, Picks - September 27, 2025

Updated Sep. 27, 2025 3:04 p.m. ET

Data Skrive

The No. 1 Ohio State Buckeyes (3-0) are 8.5-point favorites when they visit the Washington Huskies (3-0) in a Big Ten matchup on Saturday, September 27, 2025 at Alaska Airlines Field at Husky Stadium. An over/under of 53.5 is set in the game.

The Buckeyes won against the Ohio Bobcats in their most recent game, 37-9. In their last game, the Huskies won versus the Washington State Cougars, 59-24.

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Ohio State vs. Washington Game Information & Odds

When: Saturday, September 27, 2025 at 3:30 p.m. ET
Location: Alaska Airlines Field at Husky Stadium in Seattle, Washington
TV: CBS
Live Box Score on FOX Sports

Ohio State vs Washington Betting Information updated as of September 27, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Ohio State	-8.5 (-111)	-331	+264	53.5	-110	-110

Ohio State vs. Washington Prediction

Pick ATS: Washington (+8.5)
Pick OU: Under (53.5)
Prediction: Washington 36, Ohio State 17

Predictions are made by the Data Skrive betting model.

Learn more about the Ohio State Buckeyes vs. the Washington Huskies game on FOX Sports!

Ohio State vs. Washington Betting Insights

Per the spread and over/under, the implied score for the game is Buckeyes 31, Huskies 22.
The Buckeyes have a 76.8% chance to claim victory in this contest per the moneyline's implied probability. The Huskies have a 27.5% implied probability.
Ohio State has covered twice in three matchups with a spread this season.
Washington has won one game against the spread this year.

Ohio State vs. Washington: 2025 Stats Comparison

	Ohio State	Washington
Off. Points per Game (Rank)	40.3 (59)	55.7 (14)
Def. Points per Game (Rank)	5.3 (1)	18.3 (27)
Turnovers Allowed (Rank)	3 (30)	1 (5)
Turnovers Forced (Rank)	4 (75)	5 (50)

Ohio State 2025 Key Players

Name	Position	Stats
Jeremiah Smith	WR	20 REC / 315 YDS / 3 TD / 105 YPG
Julian Sayin	QB	779 YDS (78.9%) / 8 TD / 3 INT
Carnell Tate	WR	12 REC / 219 YDS / 3 TD / 73 YPG
Bo Jackson	RB	217 YDS / 1 TD / 108.5 YPG / 12.1 YPC 2 REC / 21 REC YDS / 0 REC TD / 21 REC YPG
Arvell Reese	LB	20 TKL / 2 TFL / 2 SACK
Caden Curry	DL	13 TKL / 3 TFL / 2 SACK
Kayden McDonald	DL	15 TKL / 1 TFL / 1 SACK
Sonny Styles	LB	16 TKL / 0 TFL

Washington 2025 Key Players

Name	Position	Stats
Jonah Coleman	RB	347 YDS / 9 TD / 115.7 YPG / 6.8 YPC 8 REC / 150 REC YDS / 1 REC TD / 50 REC YPG
Demond Williams Jr.	QB	778 YDS (73.5%) / 6 TD / 0 INT 220 RUSH YDS / 2 RUSH TD / 73.3 RUSH YPG
Denzel Boston	WR	16 REC / 249 YDS / 3 TD / 83 YPG
Adam Mohammed	RB	145 YDS / 2 TD / 48.3 YPG / 5.4 YPC 4 REC / 69 REC YDS / 0 REC TD / 23 REC YPG
Jacob Lane	DL	16 TKL / 3 TFL / 1.5 SACK
Alex McLaughlin	DB	15 TKL / 1 TFL / 2 INT / 2 PD
Makell Esteen	DB	14 TKL / 0 TFL / 0.5 SACK / 1 INT
Taariq Al-Uqdah	LB	14 TKL / 1 TFL / 0.5 SACK