Ohio State vs. Minnesota Prediction, Odds, Picks - October 4, 2025

Updated Oct. 4, 2025 3:05 p.m. ET

Data Skrive

The No. 1 Ohio State Buckeyes (4-0), who have college football's first-ranked scoring defense, meet the Minnesota Golden Gophers (3-1) and their 25th-ranked scoring defense on Saturday, October 4, 2025. The Buckeyes are heavy, 23.5-point favorites. The point total for the contest is set at 43.5.

The Buckeyes beat the Washington Huskies, 24-6, in their most recent contest. Last time around, the Golden Gophers defeated the Rutgers Scarlet Knights, with 31-28 being the final score.

Keep up with college football all season on FOX Sports.

Ohio State vs. Minnesota Game Information & Odds

When: Saturday, October 4, 2025 at 7:30 p.m. ET
Location: Ohio Stadium in Columbus, Ohio
TV: NBC
Live Box Score on FOX Sports

Ohio State vs Minnesota Betting Information updated as of October 4, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Ohio State	-23.5 (-111)	-3333	+1350	43.5	-106	-118

Ohio State vs. Minnesota Prediction

Pick ATS: Ohio State (-23.5)
Pick OU: Under (43.5)
Prediction: Ohio State 33, Minnesota 5

Predictions are made by the Data Skrive betting model.

Learn more about the Ohio State Buckeyes vs. the Minnesota Golden Gophers game on FOX Sports!

Ohio State vs. Minnesota Betting Insights

Based on the spread and over/under, the implied score for the game is Buckeyes 34, Golden Gophers 10.
The Buckeyes have a 97.1% chance to win this game per the moneyline's implied probability. The Golden Gophers have a 6.9% implied probability.
Ohio State has compiled a 3-1-0 ATS record so far this year.
Minnesota has covered once in four games with a spread this season.

Ohio State vs. Minnesota: Head-to-Head

Ohio State has a 2-0 record against Minnesota in their last two matchups.
The Buckeyes own a 2-0 record ATS in those games, while the two teams have gone over the point total on one occasion.
Over their last two head-to-head matchups, Ohio State has scored 82 points, while Minnesota has compiled 34.

Ohio State vs. Minnesota: 2025 Stats Comparison

	Ohio State	Minnesota
Off. Points per Game (Rank)	36.3 (56)	33.5 (70)
Def. Points per Game (Rank)	5.5 (1)	16.3 (19)
Turnovers Allowed (Rank)	4 (25)	4 (25)
Turnovers Forced (Rank)	4 (93)	6 (51)

Ohio State 2025 Key Players

Name	Position	Stats
Julian Sayin	QB	987 YDS (78.8%) / 10 TD / 3 INT
Jeremiah Smith	WR	28 REC / 396 YDS / 4 TD / 99 YPG
CJ Donaldson	RB	190 YDS / 3 TD / 47.5 YPG / 4.5 YPC 4 REC / 26 REC YDS / 1 REC TD / 8.7 REC YPG
Carnell Tate	WR	15 REC / 252 YDS / 3 TD / 63 YPG
Caden Curry	DL	24 TKL / 8 TFL / 5 SACK
Kayden McDonald	DL	21 TKL / 4 TFL / 3 SACK
Arvell Reese	LB	25 TKL / 2 TFL / 2 SACK
Sonny Styles	LB	22 TKL / 0 TFL

Minnesota 2025 Key Players

Name	Position	Stats
Drake Lindsey	QB	958 YDS (65.8%) / 7 TD / 2 INT -25 RUSH YDS / 1 RUSH TD / -6.3 RUSH YPG
Fame Ijeboi	RB	173 YDS / 1 TD / 57.7 YPG / 4.9 YPC 4 REC / 33 REC YDS / 1 REC TD / 11 REC YPG
Javon Tracy	WR	12 REC / 204 YDS / 2 TD / 51 YPG
Lemeke Brockington	WR	15 REC / 177 YDS / 1 TD / 59 YPG
Anthony Smith	DL	10 TKL / 4 TFL / 4.5 SACK
Devon Williams	LB	29 TKL / 1 TFL / 1.5 SACK
Koi Perich	DB	19 TKL / 2 TFL / 1 SACK
Maverick Baranowski	LB	19 TKL / 3 TFL / 1 SACK